| Abnormalities of homocysteine and B vitamins in the nephrotic syndrome. | |
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MedLine Citation:
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PMID: 17276499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: The nephrotic syndrome is associated with heightened risk for arterial and venous thrombosis. Multiple derangements of hemostasis and acquired risk factors such as hyperlipidemia and hypertension contribute to this risk. The prevalence in the nephrotic syndrome of high circulating levels of homocysteine and of low levels of the B vitamins that are involved in its metabolism, which may play a role in thrombosis, is not well defined. MATERIALS AND METHODS: In 84 patients with nephrotic syndrome and 84 sex- and age-matched controls, hemostasis variables and the circulating levels of total homocysteine (tHcy), vitamin B(6), B(12) and folates were measured. RESULTS: tHcy levels were higher, vitamin B(6) and vitamin B(12) levels were lower in nephrotic patients than in controls. The association of low vitamin B(6) levels with the nephrotic syndrome was independent of any other alteration associated with the disease. Eighty-two percent of patients with the nephrotic syndrome had vitamin B(6) levels falling in the lowest quartile of the normal distribution. Antithrombin deficiency, factor V Leiden, antiphospholipid antibodies, hypertension, dyslipidemia, were more frequent in patients with the nephrotic syndrome than in controls. CONCLUSIONS: Patients with the nephrotic syndrome have multiple risk factors for thrombosis. We report that they frequently have low circulating levels of vitamin B(6), which associate with a heightened risk for venous and arterial thrombosis. |
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Authors:
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Gian Marco Podda; Federico Lussana; Gabriella Moroni; Elena M Faioni; Rossana Lombardi; Gessica Fontana; Claudio Ponticelli; Claudio Maioli; Marco Cattaneo |
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Publication Detail:
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Type: Journal Article Date: 2007-02-05 |
Journal Detail:
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Title: Thrombosis research Volume: 120 ISSN: 0049-3848 ISO Abbreviation: Thromb. Res. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-08-24 Completed Date: 2007-11-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0326377 Medline TA: Thromb Res Country: United States |
Other Details:
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Languages: eng Pagination: 647-52 Citation Subset: IM |
Affiliation:
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Centro Emofilia e Trombosi "Angelo Bianchi Bonomi", Dipartmento di Medicina Interna e Dermatologia, Fondazione I.R.C.C.S. Ospedale Maggiore, Mangiagalli e Regina Elena, Università di Milano, Italy. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antibodies, Antiphospholipid / chemistry Antithrombins / deficiency Factor V / metabolism Female Folic Acid / metabolism Homocysteine / metabolism* Humans Hyperlipidemias / diagnosis Hypertension / diagnosis Male Middle Aged Nephrotic Syndrome / metabolism, pathology* Risk Risk Factors Vitamin B 12 / metabolism Vitamin B 6 / metabolism Vitamin B Complex / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antiphospholipid; 0/Antithrombins; 0/factor V Leiden; 12001-76-2/Vitamin B Complex; 454-28-4/Homocysteine; 59-30-3/Folic Acid; 68-19-9/Vitamin B 12; 8059-24-3/Vitamin B 6; 9001-24-5/Factor V |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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