| Abnormalities of hemostasis in chronic liver disease: reappraisal of their clinical significance and need for clinical and laboratory research. | |
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MedLine Citation:
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PMID: 17316874 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The derangement of hemostasis in patients with chronic liver disease has long been thought to be causally related to the bleeding events seen in these patients. However, the relatively poor correlation between bleeding and the peripheral indices of hemostasis together with the recent findings of the literature that thrombin generation as well as platelet adhesion are normal in these patients challenge this concept and question the usefulness of conventional tests in assessing the hemorrhagic risk, as well as the appropriateness of therapeutic strategies meant to correct abnormal hemostasis tests. This article reviews the abnormalities of primary hemostasis (interaction between platelets and vessel wall), coagulation (thrombin generation) and fibrinolysis in patients with chronic liver disease and proposes areas needing further clinical and laboratory research. |
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Authors:
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Armando Tripodi; Pier Mannuccio Mannucci |
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Publication Detail:
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Type: Journal Article; Review Date: 2007-02-05 |
Journal Detail:
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Title: Journal of hepatology Volume: 46 ISSN: 0168-8278 ISO Abbreviation: J. Hepatol. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-03-19 Completed Date: 2007-06-06 Revised Date: 2008-04-08 |
Medline Journal Info:
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Nlm Unique ID: 8503886 Medline TA: J Hepatol Country: England |
Other Details:
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Languages: eng Pagination: 727-33 Citation Subset: IM |
Affiliation:
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Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, University and IRCCS Ospedale Maggiore, Mangiagalli and Regina Elena Foundation, Via Pace 9, 20122-Milano, Italy. armando.tripodi@unimi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biomedical Research Blood Coagulation Chronic Disease Fibrinolysis Hemostasis* Humans Liver Diseases / blood*, complications Thrombin / biosynthesis Thrombophilia / etiology |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.5/Thrombin |
| Comments/Corrections | |
Comment In:
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J Hepatol. 2008 Feb;48(2):371-2; author reply 372-3
[PMID:
18093682
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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