| Abnormalities of the foetal cerebral cortex. | |
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MedLine Citation:
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PMID: 19235759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prenatal ultrasound has concentrated on readily visible cerebral structures including head size, shape, ventricles, CSP (cavum septi pellucidi), cerebellar size/vermian presence and cisterna magna. However, apart from these easily visible structures it is important to evaluate the brain itself. Patients who initially appear to have mild isolated findings such as borderline ventriculomegaly in fact can have many more subtle findings that significantly alter prognosis and management that can be detected on detailed examination of the brain. There has been rapid evolution in imaging these foetuses, especially with neurosonography and MRI, and a revolution in understanding the underlying genetic and biochemical mechanisms. There is increasing emphasis to detect cortical abnormalities as early as possible. This article reviews development of the cerebral cortex, the classification, aetiologies and clinical manifestations of cortical disorders, normal and abnormal appearances at ultrasound and MRI, and approaches to investigation. |
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Authors:
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Ants Toi; David Chitayat; Susan Blaser |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Prenatal diagnosis Volume: 29 ISSN: 0197-3851 ISO Abbreviation: Prenat. Diagn. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-04-06 Completed Date: 2009-06-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: England |
Other Details:
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Languages: eng Pagination: 355-71 Citation Subset: IM |
Affiliation:
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Department of Medical Imaging, Mount Sinai Hospital and University Health Network, University of Toronto, Toronto, Ontario, Canada. a.toi@utoronto.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Movement Cerebral Cortex / abnormalities*, embryology* Female Gestational Age Humans Magnetic Resonance Imaging Microcephaly / embryology Neurons Pregnancy Prenatal Diagnosis* Risk Factors Ultrasonography, Prenatal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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