Document Detail

Abnormalities of erythrocyte stromal lipids in atresia of the intrahepatic bile ducts.
MedLine Citation:
PMID:  6179489     Owner:  NLM     Status:  MEDLINE    
Detailed analysis of plasma and erythrocytes lipid composition of patient with intrahepatic biliary atresia is presented. Abnormalities have been outlined and are characterized as following: (1) an increase of total cholesterol compounds and total phospholipids in serum; (2) an increase of free cholesterol and lecithin up to 50 per cent of total phosphatides in red cells; (3) the fatty-acids pattern isolated from total phospholipids of red cells shows a rise of palmitic and palmitoleic acids and a decrease of stearic and longer-chain fatty acids; (4) in PC and PE of red cells, there is an overall tendency for the degree of unsaturation of long-chain fatty acids to increase. In addition to these lipid changes, it was demonstrated by polyacrylamide-gel electrophoresis that the composition of membrane proteins was normal. It is of particular interest to establish whether these abnormalities are either induced by complex metabolic pathways and exchange processes between the lipids of circulating erythrocytes and the altered lipids of serum environment or are the direct result of modified hepatic cellular or enzymatic function.
S Chapelle; C Franois; J M Chantraine
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives internationales de physiologie et de biochimie     Volume:  90     ISSN:  0003-9799     ISO Abbreviation:  Arch. Int. Physiol. Biochim.     Publication Date:  1982 Apr 
Date Detail:
Created Date:  1982-09-24     Completed Date:  1982-09-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0405355     Medline TA:  Arch Int Physiol Biochim     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  35-48     Citation Subset:  IM    
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MeSH Terms
Bile Ducts, Intrahepatic / abnormalities*
Cholesterol / blood
Erythrocytes / metabolism*
Fatty Acids / blood
Lipids / blood*
Membrane Proteins / blood
Phospholipids / blood
Reg. No./Substance:
0/Fatty Acids; 0/Lipids; 0/Membrane Proteins; 0/Phospholipids; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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