Document Detail


Abnormalities of erythrocyte sodium transport in reflux nephropathy.
MedLine Citation:
PMID:  8880562     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypertension is a complication of reflux nephropathy commonly occurring during adolescence and young adult life. We studied cellular sodium transport in an adolescent cohort with this condition as abnormal sodium transport is a feature of human hypertension. Thirty males and 52 females with reflux nephropathy, (median age 20.3 years) had erythrocyte ouabain sensitive sodium-potassium ATPase (Na/K ATPase) pump site number (Bmax) and red cell sodium concentration (RBC Na+) measured in 1988. Six years later, 55 of those had red cell sodium-lithium counter transport (LCT) measured. On both occasions, their renal function and blood pressure (BP) were determined. Bmax in the study group (median 10.3 nmol/l) was significantly less than that of controls (median 11.45 nmol/l). Nine patients who were diagnosed as having hypertension during the 6 year study period appeared to have a lower Bmax compared with that of normotensives in the group. RBC Na+ and LCT of the study group were not significantly different from that of controls. The Na/K ATPase activity is diminished, and sodium-lithium counter transport is unchanged in reflux nephropathy. Further study is needed to ascertain the link between these observations and the onset of high BP.
Authors:
C D Goonasekera; H Jardim; V Shah; M J Dillon
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of human hypertension     Volume:  10     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1997-01-16     Completed Date:  1997-01-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  473-6     Citation Subset:  IM    
Affiliation:
Division of Clinical Sciences, Institute of Child Health, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antiporters / blood
Biological Transport
Erythrocytes / metabolism*
Female
Humans
Male
Sodium / blood*
Urinary Tract Infections / blood*,  etiology*
Vesico-Ureteral Reflux / complications*
Chemical
Reg. No./Substance:
0/Antiporters; 0/sodium-lithium countertransporter; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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