Document Detail

Abnormalities of diaphragmatic muscle in neonates with ventilated lungs.
MedLine Citation:
PMID:  3142983     Owner:  NLM     Status:  MEDLINE    
Several infants and neonates who had received long-term ventilatory assistance had subnormal diaphragmatic muscle mass on gross necropsy examination. We conducted a retrospective study of our hospital infant necropsy files to determine whether prolonged ventilatory support was associated with diminution in myofiber cross-sectional area selectively affecting the diaphragm. We found that long-term ventilatory assistance may predispose diaphragmatic myofibers to disuse atrophy or to failure or normal growth. This phenomenon may contribute to difficulties in weaning infants from ventilatory support.
A S Knisely; S M Leal; D B Singer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  113     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-01-10     Completed Date:  1989-01-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1074-7     Citation Subset:  AIM; IM    
Program in Developmental Pathology, Brown University, Providence, RI.
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MeSH Terms
Diaphragm / pathology*
Infant, Newborn
Long-Term Care
Muscular Atrophy / pathology
Respiration, Artificial*
Respiratory Distress Syndrome, Newborn / pathology*
Retrospective Studies

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