| Abnormalities detected on transvaginal ultrasonography in tamoxifen-treated postmenopausal breast cancer patients may represent endometrial cystic atrophy. | |
MedLine Citation:
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PMID: 9662294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This study was conducted to examine the histopathologic changes in tamoxifen-treated postmenopausal patients with endometrial thickness > or = 5 mm with transvaginal ultrasonography. STUDY DESIGN: Thirty-five tamoxifen-treated postmenopausal breast cancer patients underwent transvaginal pelvic ultrasonography with endometrial thickness > or = 5 mm followed by either curettage-hysteroscopy (n = 24), or hysterectomy (n = 11). Endometrial histopathologic findings were examined. RESULTS: Overall, endometrial polyps were the most common histopathologic finding (23 of 35 patients). Endometrial cystic atrophy was uncommonly detected in patients undergoing curettage-hysteroscopy (1 of 24 patients) compared with patients undergoing hysterectomy (9 of 11 patients). No cases of endometrial cancer or hyperplasia were detected. CONCLUSIONS: Endometrial polyps were a frequent finding in tamoxifen-treated postmenopausal women who had endometrial thickness > or = 5 mm with the use of transvaginal ultrasonography. Endometrial cystic atrophy may explain "thickened endometrium" on transvaginal ultrasonography in this patient population with no evidence of endometrial polyps, hyperplasia, or adenocarcinoma after surgical evaluation. |
Authors:
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K F McGonigle; S L Shaw; S A Vasilev; T Odom-Maryon; S Roy; J F Simpson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 178 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-07-30 Completed Date: 1998-07-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1145-50 Citation Subset: AIM; IM |
Affiliation:
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Department of Gynecology, City of Hope National Medical Center, Duarte, California, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antineoplastic Agents, Hormonal / adverse effects*, therapeutic use Atrophy Breast Neoplasms / drug therapy* Curettage Cysts / ultrasonography* Endometrium / drug effects, pathology, ultrasonography* Female Humans Hysterectomy Middle Aged Polyps / chemically induced, pathology, ultrasonography Postmenopause / physiology* Retrospective Studies Tamoxifen / adverse effects*, therapeutic use Uterine Diseases / chemically induced, pathology, ultrasonography |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Hormonal; 10540-29-1/Tamoxifen |
| Comments/Corrections | |
Comment In:
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Am J Obstet Gynecol. 1999 Jan;180(1 Pt 1):252
[PMID:
9914614
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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