Document Detail

Abnormalities detected on transvaginal ultrasonography in tamoxifen-treated postmenopausal breast cancer patients may represent endometrial cystic atrophy.
MedLine Citation:
PMID:  9662294     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study was conducted to examine the histopathologic changes in tamoxifen-treated postmenopausal patients with endometrial thickness > or = 5 mm with transvaginal ultrasonography. STUDY DESIGN: Thirty-five tamoxifen-treated postmenopausal breast cancer patients underwent transvaginal pelvic ultrasonography with endometrial thickness > or = 5 mm followed by either curettage-hysteroscopy (n = 24), or hysterectomy (n = 11). Endometrial histopathologic findings were examined. RESULTS: Overall, endometrial polyps were the most common histopathologic finding (23 of 35 patients). Endometrial cystic atrophy was uncommonly detected in patients undergoing curettage-hysteroscopy (1 of 24 patients) compared with patients undergoing hysterectomy (9 of 11 patients). No cases of endometrial cancer or hyperplasia were detected. CONCLUSIONS: Endometrial polyps were a frequent finding in tamoxifen-treated postmenopausal women who had endometrial thickness > or = 5 mm with the use of transvaginal ultrasonography. Endometrial cystic atrophy may explain "thickened endometrium" on transvaginal ultrasonography in this patient population with no evidence of endometrial polyps, hyperplasia, or adenocarcinoma after surgical evaluation.
K F McGonigle; S L Shaw; S A Vasilev; T Odom-Maryon; S Roy; J F Simpson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  178     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-07-30     Completed Date:  1998-07-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1145-50     Citation Subset:  AIM; IM    
Department of Gynecology, City of Hope National Medical Center, Duarte, California, USA.
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MeSH Terms
Aged, 80 and over
Antineoplastic Agents, Hormonal / adverse effects*,  therapeutic use
Breast Neoplasms / drug therapy*
Cysts / ultrasonography*
Endometrium / drug effects,  pathology,  ultrasonography*
Middle Aged
Polyps / chemically induced,  pathology,  ultrasonography
Postmenopause / physiology*
Retrospective Studies
Tamoxifen / adverse effects*,  therapeutic use
Uterine Diseases / chemically induced,  pathology,  ultrasonography
Reg. No./Substance:
0/Antineoplastic Agents, Hormonal; 10540-29-1/Tamoxifen
Comment In:
Am J Obstet Gynecol. 1999 Jan;180(1 Pt 1):252   [PMID:  9914614 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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