| Abnormalities of the contrast re-circulation phase in cerebral tumors demonstrated using dynamic susceptibility contrast-enhanced imaging: a possible marker of vascular tortuosity. | |
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MedLine Citation:
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PMID: 10713941 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dynamic susceptibility contrast-enhanced magnetic resonance (MR) imaging in tumors is restricted by relaxivity effects, which may obscure any abnormality of first-pass kinetics in the re-circulation phase. The purposes of this study were a) to document the magnitude of relaxivity effects with a variety of commonly used MR susceptibility imaging techniques; and b) to determine whether the re-circulation phase of the first-pass curve in tumors differs from that in normal tissue. We have confirmed that residual relaxivity effects can be eliminated from dynamic susceptibility contrast-enhanced data by several techniques. Application of these methods to enhancing vascular tumors allows detection of abnormalities in the re-circulation phase, which would otherwise be obscured. These abnormalities are independent of relative cerebral blood volume (rCBV) and presumably represent deviations from the predicted gamma variat flow pattern seen in normal tissues. We believe that the parameter rR described here provides an indicator of the chaotic nature of neovascular angiogenesis, which may be of benefit in diagnosis and management. |
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Authors:
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A Kassner; D J Annesley; X P Zhu; K L Li; I D Kamaly-Asl; Y Watson; A Jackson |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 11 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2000 Feb |
Date Detail:
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Created Date: 2000-04-05 Completed Date: 2000-04-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 103-13 Citation Subset: IM |
Affiliation:
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Philips Medical Systems, Hammersmith, London, United Kingdom. ak@medphysics.leeds.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain
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pathology* Brain Neoplasms / blood supply, pathology* Cerebrovascular Circulation / physiology* Contrast Media Female Gadolinium DTPA / diagnostic use Humans Injections, Intravenous Magnetic Resonance Imaging / methods* Male Middle Aged Phantoms, Imaging |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 122795-43-1/gadodiamide; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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