Document Detail

Abnormalities of chromosome 12p13 and malignant proliferation of eosinophils: a nonrandom association.
MedLine Citation:
PMID:  3478077     Owner:  NLM     Status:  MEDLINE    
Four patients representing a spectrum of haematological malignancies are reported. Two patients had Philadelphia chromosome negative myeloproliferative disorders, one had acute lymphoblastic leukaemia and one had eosinophilic leukaemia. In each case eosinophilia was present and demonstrated to be part of the malignancy by the association of clonally abnormal metaphases with eosinophil granules. Abnormalities involving the short arm of chromosome 12 (12p13) were a constant feature in all four cases and therefore a nonrandom association between this chromosome region and malignant eosinophil proliferation is proposed.
P Keene; B Mendelow; M R Pinto; W Bezwoda; L MacDougall; G Falkson; P Ruff; R Bernstein
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  67     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1987-12-16     Completed Date:  1987-12-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  25-31     Citation Subset:  IM    
Department of Human Genetics, School of Pathology, South African Institute for Medical Research, Johannesburg.
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MeSH Terms
Acute Disease
Child, Preschool
Chromosomes, Human, Pair 12 / ultrastructure*
Eosinophilia / genetics*
Leukemia / genetics
Leukemia, Lymphoid / genetics
Middle Aged
Myeloproliferative Disorders / genetics
Translocation, Genetic*

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