| Abnormalities of the Upper Extremities on Fetal MRI. | |
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MedLine Citation:
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PMID: 21308835 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: In view of the increasing use of fetal magnetic resonance imaging (MRI) as an adjunct to prenatal ultrasonography (US), we sought to demonstrate the visualization of upper extremity abnormalities and associated defects on MRI, with regard to fetal outcomes and compared to US. METHODS: This retrospective study included 29 fetuses with upper extremity abnormalities that were positively depicted with fetal MRI and confirmed by postnatal assessment or autopsy. On a 1.5 Tesla unit, dedicated sequences were applied to image the extremities. CNS and extra-CNS anomalies were assessed to define extremity abnormalities as isolated or complex with associated defects. Fetal outcome was identified from medical records. The MRI and US findings were compared. RESULTS: Isolated upper extremity abnormalities were found in 3/29 (10.3%) fetuses. Complex abnormalities were demonstrated in 26/29 (89.7%) fetuses, including postural extremity disorders (21/26) and structural extremity abnormalities (15/26). Associated defects involved: face (15/26); musculoskeletal system (14/26); thorax and cardio/pulmonary system (12/26); lower extremities (12/26); brain and skull (10/26); and abdomen (8/26). Of 29 cases, 18 (62.1%) pregnancies were delivered and 11 (37.9%) were terminated. MRI and US were compared in 27/29 cases: the diagnosis was concordant in 14/27 (51.9%) cases, and additional MRI findings were made in 13/27 (48.1%) cases. CONCLUSIONS: Our results demonstrate that the visualization of upper extremity abnormalities on fetal MRI enables the differentiation between isolated and complex defects, which may be related to poor fetal prognosis. MRI mostly confirms the US diagnosis, but may provide additional findings in certain cases. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd. |
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Authors:
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Stefan F Nemec; Gregor Kasprian; Peter C Brugger; Dieter Bettelheim; Gabriele Amann; Ursula Nemec; Siegfried Rotmensch; John M Graham; David L Rimoin; Ralph S Lachman; Daniela Prayer |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-24 |
Journal Detail:
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Title: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology Volume: - ISSN: 1469-0705 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-2-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9108340 Medline TA: Ultrasound Obstet Gynecol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd. |
Affiliation:
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Department of Radiology, Division of Neuroradiology and Musculoskeletal Radiology, Medical University Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria; Medical Genetics Institute, Cedars Sinai Medical Center, 8700 Beverly Boulevard, PACT Suite 400, Los Angeles, California 90048, USA. stefan.nemec@meduniwien.ac.at, stefan.nemec@cshs.org. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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