Document Detail

Abnormal zinc content in human milk. Risk for development of nutritional zinc deficiency in infants.
MedLine Citation:
PMID:  2718997     Owner:  NLM     Status:  MEDLINE    
An abnormally low concentration of zinc in mother's milk has been associated with clinical nutritional zinc deficiency in premature and term newborns. Defective mammary gland secretion of zinc was suggested as the causative factor. We investigated whether low milk zinc concentration might be reflected in an abnormality of the distribution of zinc between casein, whey, and fat components of the milk, in a reduction in the levels of milk citrate, a zinc-binding ligand, or in abnormal levels of copper and iron. Milk from mothers of four low-birth-weight infants was identified as being deficient in zinc content for the lactational stage. One infant had clinical signs of nutritional zinc deficiency. For two of the three infants with subclinical deficiencies in whom balance study data were available, the apparent zinc balance was negative (-5.7 and -6.0 mumol/kg per day). These milks were examined for content and distribution of zinc, copper, and iron, and citrate concentration. Although total zinc concentration (4.5 to 17.2 mumol/L) was below the 95% prediction interval (15.2 to 59.7 mumol/L) for the lactational stage, the distribution of zinc was normal between milk components. Levels of citrate (1.46 to 5.13 mmol/L) were also within normal limits, as were levels of copper (0.27 to 0.85 mumol/L and iron (0.41 to 1.13 mumol/L). We concluded that there was no indirect evidence of a secretory abnormality in milk zinc deficiency, but speculated that there might instead be an abnormality of zinc uptake by the mammary gland from the plasma.
S A Atkinson; D Whelan; R K Whyte; B Lönnerdal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of diseases of children (1960)     Volume:  143     ISSN:  0002-922X     ISO Abbreviation:  Am. J. Dis. Child.     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-06-09     Completed Date:  1989-06-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370471     Medline TA:  Am J Dis Child     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  608-11     Citation Subset:  AIM; IM    
Department of Pediatrics, McMaster University, Hamilton, Canada.
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MeSH Terms
Breast Feeding
Citrates / analysis
Citric Acid
Infant Nutrition Disorders / etiology*
Infant, Low Birth Weight
Infant, Newborn
Milk Proteins / analysis
Milk, Human / analysis*
Risk Factors
Zinc / analysis,  deficiency*
Reg. No./Substance:
0/Citrates; 0/Milk Proteins; 7440-66-6/Zinc; 77-92-9/Citric Acid

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