| Abnormal water diffusivity in corticostriatal projections in children with Tourette syndrome. | |
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MedLine Citation:
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PMID: 20162597 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The fronto-striato-thalamic circuit has been implicated in the pathomechanism of Tourette Syndrome (TS). To study white and gray matter comprehensively, we used a novel technique called Tract-Based Spatial Statistics (TBSS) combined with voxel-based analysis (VBA) of diffusion tensor MR images in children with TS as compared to typically developing controls. These automated and unbiased methods allow analysis of cerebral white matter and gray matter regions. We compared 15 right-handed children with TS (mean age: 11.6 ± 2.5 years, 12 males) to 14 age-matched right-handed healthy controls (NC; mean age: 12.29 ± 3.2 years, 6 males). Tic severity and neurobehavioral scores were correlated with FA and ADC values in regions found abnormal by these methods. For white matter, TBSS analysis showed regions of increased ADC in the corticostriatal projection pathways including left external capsule and left and right subcallosal fasciculus pathway in TS group compared to NC group. Within the TS group, ADC for the left external capsule was negatively associated with tic severity (r= -0.586, P = 0.02). For gray matter, VBA revealed increased ADC for bilateral orbitofrontal cortex, left putamen, and left insular cortex. ADC for the right and left orbitofrontal cortex was highly correlated with internalizing problems (r = 0.665; P = 0.009, r = 0.545; P = 0.04, respectively). Altogether, this analysis revealed focal diffusion abnormalities in the corticostriatal pathway and in gray matter structures involved in the fronto-striatal circuit in TS. These diffusion abnormalities could serve as a neuroimaging marker related to tic severity and neurobehavioral abnormalities in TS subjects. |
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Authors:
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Rajkumar Munian Govindan; Malek I Makki; Benjamin J Wilson; Michael E Behen; Harry T Chugani |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Human brain mapping Volume: 31 ISSN: 1097-0193 ISO Abbreviation: Hum Brain Mapp Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-19 Completed Date: 2011-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9419065 Medline TA: Hum Brain Mapp Country: United States |
Other Details:
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Languages: eng Pagination: 1665-74 Citation Subset: IM |
Copyright Information:
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© 2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Pediatrics, Children's Hospital of Michigan, School of Medicine, Wayne State University, Detroit, Michigan, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Anisotropy Brain Mapping Child Corpus Striatum / physiopathology* Diffusion Tensor Imaging / methods* Female Frontal Lobe / physiopathology* Humans Image Processing, Computer-Assisted Male Nerve Fibers, Unmyelinated / physiology Neural Pathways / physiopathology Severity of Illness Index Thalamus / physiopathology Tourette Syndrome / physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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