Document Detail

Abnormal vitamin K metabolism in the presence of normal clotting factor activity in factory workers exposed to 4-hydroxycoumarins.
MedLine Citation:
PMID:  3964529     Owner:  NLM     Status:  MEDLINE    
The case histories of two patients exposed to the novel anticoagulants brodifacoum and difenacoum are reported. Abnormal vitamin K1 metabolism, as indicated by elevated vitamin K1 2,3-epoxide plasma concentrations after i.v. administration of vitamin K1, could be detected for more than 18 months after exposure to the anticoagulants. There was a marked prolongation of prothrombin time (greater than 50 s) in both cases, at the time of exposure. However, subsequent haematological investigations (prothrombin time and vitamin K-dependent clotting factor activity) have been shown to be normal in both cases for at least 18 months. These cases confirm the long-acting nature of brodifacoum and difenacoum and present an apparent dissociation between the effect of coumarin anticoagulants on vitamin K1 metabolism and clotting factor activity.
B K Park; I A Choonara; B P Haynes; A M Breckenridge; R G Malia; F E Preston
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  21     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-05-28     Completed Date:  1986-05-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  289-93     Citation Subset:  IM    
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MeSH Terms
4-Hydroxycoumarins / adverse effects*,  blood
Blood Coagulation Disorders / chemically induced*
Blood Coagulation Tests
Occupational Diseases / blood,  chemically induced*
Prothrombin Time
Vitamin K 1 / analogs & derivatives,  blood,  diagnostic use,  metabolism*
Reg. No./Substance:
0/4-Hydroxycoumarins; 25486-55-9/vitamin K1 oxide; 56073-07-5/difenacoum; 56073-10-0/bromfenacoum; 84-80-0/Vitamin K 1

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