Document Detail


Abnormal vascular architecture at the placental-maternal interface in placenta increta.
MedLine Citation:
PMID:  22939721     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: The objective of the study was to characterize the vascular architecture at the placental-maternal interface in pregnancies complicated by placenta increta and normal pregnancies.
STUDY DESIGN: Vessel numbers and cross-section area density and spatial and area distributions in 13 placenta-increta placental beds were compared with 9 normal placental beds using computer-assisted image analysis of whole-slide CD31 immunolabeled sections.
RESULTS: The total areas occupied by vessels in normal and placenta-increta placental beds were comparable, but vessels were significantly sparser and larger in the latter. Moreover, placenta-increta-vessel distributions (area and distance from the placental-myometrial junction) were more heterogeneous.
CONCLUSION: Size and spatial organization of the placenta-increta vascular architecture at the placental-maternal interface differed from normal and might partially explain the severe hemorrhage observed during placenta-increta deliveries.
Authors:
Frédéric Chantraine; Silvia Blacher; Sarah Berndt; José Palacios-Jaraquemada; Nanette Sarioglu; Michelle Nisolle; Thorsten Braun; Carine Munaut; Jean-Michel Foidart
Publication Detail:
Type:  Journal Article     Date:  2012-07-07
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  207     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  188.e1-9     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Mosby, Inc. All rights reserved.
Affiliation:
Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire, Hôpital la Citadelle, Liège, Belgium; Laboratory of Tumor and Development Biology, Centre Hospitalier Universitaire, GIGA-Cancer, University of Liège, Liège, Belgium.
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