| Abnormal urethral motor function is common in female stress, mixed, and urge incontinence. | |
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MedLine Citation:
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PMID: 16897750 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To investigate the urethral motor function in incontinent women. MATERIALS AND METHODS: The intraurethral pressure was measured continuously in the high-pressure zone of the urethra at rest and during repeated short squeezes around the microtip transducer catheter in a group of 205 women with clinically manifest urinary incontinence (severe), and compared with the findings of investigations in 87 middle-aged women (53-63 years) with treatment naïve incontinence (mild-to-moderate) and healthy controls. RESULTS: Women with established incontinence significantly (P < 0.001) more often (66%) had a pressure fall during or immediately following squeeze than women with treatment naïve incontinence (35%) or asymptomatic women (25%). The acceleration of urinary flow and the maximal flow rate were significantly (P < 0.01) increased in patients with incontinence: acceleration was 13 +/- 2.2 (17.8), 20 +/- 2.8 (18.9), and 32 +/- 4.9 (24.9) degrees (mean +/- SEM; SD) for incontinence, naïve incontinence and no incontinence, respectively; maximum urinary flow rate was 23, 22, and 16 ml/sec. No statistical differences in any of these measures were seen when stress and urge incontinence were compared. CONCLUSION: Women with stress, urge, and mixed urinary incontinence seem to have a primary neuromuscular disorder in the urethra, which presents itself as an overactive opening mechanism with a urethral pressure fall instead of a pressure increase on provocation during the filling phase of the bladder, and during bladder emptying a more efficient opening of the bladder outlet than in normal women. We suggest that one and the same pathophysiological mechanism participates in female stress, urge, and mixed incontinence. |
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Authors:
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Anders Mattiasson; Pia Teleman |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurourology and urodynamics Volume: 25 ISSN: 0733-2467 ISO Abbreviation: Neurourol. Urodyn. Publication Date: 2006 |
Date Detail:
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Created Date: 2006-10-26 Completed Date: 2007-01-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8303326 Medline TA: Neurourol Urodyn Country: United States |
Other Details:
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Languages: eng Pagination: 703-8 Citation Subset: IM |
Copyright Information:
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(c) 2006 Wiley-Liss, Inc. |
Affiliation:
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Department of Urology, Lund University Hospital, Lund, Sweden. anders.mattiasson@urokir.lu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Humans Middle Aged Muscle Contraction / physiology Urethra / physiopathology* Urinary Bladder / physiopathology Urinary Catheterization Urinary Incontinence / physiopathology* Urinary Incontinence, Stress / physiopathology* Urodynamics / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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