Document Detail

Abnormal umbilical artery Doppler waveforms and cord blood inhibin a and inhibin B levels.
MedLine Citation:
PMID:  14593237     Owner:  NLM     Status:  MEDLINE    
Inhibin A and inhibin B are glycoprotein hormones produced by human placenta and by several fetal organs during pregnancy. They are secreted in maternal circulation in increasing amounts from early until term pregnancy, and in umbilical cord blood levels are significantly lower than in maternal serum and do not differ from mid-pregnancy to term gestation. In the present study, we aimed to determine whether secretion of inhibin A and inhibin B into the fetal circulation is increased in pregnancies complicated by umbilical-placental vascular insufficiency. A group of women (n = 13) with abnormal Doppler umbilical artery flow velocimetry and a group of control women (n = 11) with uncomplicated term pregnancies and normal umbilical artery flow velocity waveforms were studied. In each woman, inhibin A and inhibin B concentrations were estimated in umbilical cord artery and vein. In the two groups of women, mean inhibin A levels did not differ between umbilical cord artery and vein. In addition, no difference was retrieved both in umbilical cord artery and vein values between healthy controls and patients with abnormal Doppler umbilical artery flow velocimetry. On the contrary, inhibin B levels were significantly higher in samples from umbilical cord vein than artery, in both groups of pregnant women (both p < 0.001). However, women with abnormal Doppler umbilical artery flow velocimetry had inhibin B levels significantly higher than healthy controls (p = 0.005) only in the umbilical cord artery, but not in the vein. In the presence of abnormal Doppler umbilical artery flow velocity, the concentrations of inhibin B are increased in the arterial umbilical circulation, suggesting that inhibin B is released from multiple fetal sources as a response to hypoxemic stress. As inhibins may affect the hypothalamus-pituitary-adrenal axis which plays an important role in the mechanisms of adaptations to the post-natal life, inhibin B in fetal circulation might then be beneficial to a fetus whose intrauterine survival is threatened by impaired umbilical-placental blood flow.
P Florio; F M Severi; S Luisi; E Ignacchiti; G Calonaci; C Bocchi; F Petraglia
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biology of the neonate     Volume:  84     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  2003  
Date Detail:
Created Date:  2003-10-31     Completed Date:  2004-06-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  281-6     Citation Subset:  IM    
Copyright Information:
Copyright 2003 S. Karger AG, Basel
Chair of Obstetrics and Gynecology, Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy.
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MeSH Terms
Blood Flow Velocity
Fetal Blood / chemistry*
Gestational Age
Infant, Newborn
Inhibins / blood*
Placental Insufficiency / blood*,  ultrasonography*
Ultrasonography, Doppler
Umbilical Arteries / ultrasonography*
Umbilical Veins
Reg. No./Substance:
0/inhibin A; 0/inhibin B; 57285-09-3/Inhibins

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