Document Detail

Abnormal transmural repolarization process in patients with Brugada syndrome.
MedLine Citation:
PMID:  19632628     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Repolarization abnormality, especially during bradycardia, might be critical for initiation of ventricular fibrillation (VF) in patients with Brugada syndrome (BrS), but the contribution of the rate-dependent repolarization dynamics to the occurrence of VF is still unknown.
OBJECTIVE: The aim of our study was to determine the differences in rate-dependent repolarization dynamics between BrS with and without spontaneous VF and between BrS with and without SCN5A mutation.
METHODS: The subjects were 37 BrS patients with VF (VF(+) group: 10 male subjects) and without VF (VF(-) group: 27 male subjects) and 20 control subjects. Genetic analysis of SCN5A was performed in all 37 BrS patients. The relationships between QT, QTp, Tp-e, and RR intervals were obtained from Holter recordings as first linear regression lines, and the slopes of QT/RR, QTp/RR, and Tp-e/RR linear regression lines as the sensitivity of rate-dependent repolarization dynamics were compared.
RESULTS: QT/RR and Tp-e/RR slopes showed loss of a rate-dependent property in the VF(+) group compared with those in the VF(-) and control groups. There was no significant difference in QTp/RR slope among the VF(+), VF(-) and control groups. The Tp-e interval had a negative correlation with the RR interval in the VF(+) group and a positive correlation with the RR interval in the VF(-) and control groups. There was no significant difference in QT/RR, QTp/RR, and Tp-e/RR slopes between BrS patients with SCN5A mutation and those without SCN5A mutation.
CONCLUSIONS: Loss of rate-dependent QT dynamics may be associated with occurrence of VF in BrS.
Mutsuko Sangawa; Hiroshi Morita; Takaaki Nakatsu; Nobuhiro Nishii; Daiji Miura; Aya Miura; Takeshi Tada; Masato Murakami; Shigeki Hiramatsu; Satoshi Nagase; Kazufumi Nakamura; Takefumi Oka; Shinji Toyonaga; Keiichi Mashima; Shozo Kusachi; Kazuhide Yamamoto; Tohru Ohe; Kengo F Kusano
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-04
Journal Detail:
Title:  Heart rhythm : the official journal of the Heart Rhythm Society     Volume:  6     ISSN:  1556-3871     ISO Abbreviation:  Heart Rhythm     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-27     Completed Date:  2009-11-06     Revised Date:  2011-07-22    
Medline Journal Info:
Nlm Unique ID:  101200317     Medline TA:  Heart Rhythm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1163-9     Citation Subset:  IM    
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine and Dentistry, Okayama City, Okayama, Japan.
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MeSH Terms
Analysis of Variance
Brugada Syndrome / diagnosis,  genetics,  physiopathology*
Case-Control Studies
Electrocardiography, Ambulatory
Middle Aged
Muscle Proteins / genetics*
Sodium Channels / genetics*
Statistics as Topic
Ventricular Fibrillation / genetics,  physiopathology
Reg. No./Substance:
0/Muscle Proteins; 0/Sodium Channels; 0/sodium channel protein type 5 subunit alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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