| Abnormal transmural repolarization process in patients with Brugada syndrome. | |
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MedLine Citation:
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PMID: 19632628 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Repolarization abnormality, especially during bradycardia, might be critical for initiation of ventricular fibrillation (VF) in patients with Brugada syndrome (BrS), but the contribution of the rate-dependent repolarization dynamics to the occurrence of VF is still unknown. OBJECTIVE: The aim of our study was to determine the differences in rate-dependent repolarization dynamics between BrS with and without spontaneous VF and between BrS with and without SCN5A mutation. METHODS: The subjects were 37 BrS patients with VF (VF(+) group: 10 male subjects) and without VF (VF(-) group: 27 male subjects) and 20 control subjects. Genetic analysis of SCN5A was performed in all 37 BrS patients. The relationships between QT, QTp, Tp-e, and RR intervals were obtained from Holter recordings as first linear regression lines, and the slopes of QT/RR, QTp/RR, and Tp-e/RR linear regression lines as the sensitivity of rate-dependent repolarization dynamics were compared. RESULTS: QT/RR and Tp-e/RR slopes showed loss of a rate-dependent property in the VF(+) group compared with those in the VF(-) and control groups. There was no significant difference in QTp/RR slope among the VF(+), VF(-) and control groups. The Tp-e interval had a negative correlation with the RR interval in the VF(+) group and a positive correlation with the RR interval in the VF(-) and control groups. There was no significant difference in QT/RR, QTp/RR, and Tp-e/RR slopes between BrS patients with SCN5A mutation and those without SCN5A mutation. CONCLUSIONS: Loss of rate-dependent QT dynamics may be associated with occurrence of VF in BrS. |
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Authors:
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Mutsuko Sangawa; Hiroshi Morita; Takaaki Nakatsu; Nobuhiro Nishii; Daiji Miura; Aya Miura; Takeshi Tada; Masato Murakami; Shigeki Hiramatsu; Satoshi Nagase; Kazufumi Nakamura; Takefumi Oka; Shinji Toyonaga; Keiichi Mashima; Shozo Kusachi; Kazuhide Yamamoto; Tohru Ohe; Kengo F Kusano |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-05-04 |
Journal Detail:
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Title: Heart rhythm : the official journal of the Heart Rhythm Society Volume: 6 ISSN: 1556-3871 ISO Abbreviation: Heart Rhythm Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-27 Completed Date: 2009-11-06 Revised Date: 2011-07-22 |
Medline Journal Info:
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Nlm Unique ID: 101200317 Medline TA: Heart Rhythm Country: United States |
Other Details:
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Languages: eng Pagination: 1163-9 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine and Dentistry, Okayama City, Okayama, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Analysis of Variance Brugada Syndrome / diagnosis, genetics, physiopathology* Case-Control Studies Electrocardiography, Ambulatory Humans Male Middle Aged Muscle Proteins / genetics* Sodium Channels / genetics* Statistics as Topic Ventricular Fibrillation / genetics, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Muscle Proteins; 0/Sodium Channels; 0/sodium channel protein type 5 subunit alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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