Document Detail

Abnormal spread of junctional acetylcholine receptor of paraspinal muscles in scoliosis associated with syringomyelia.
MedLine Citation:
PMID:  17108413     Owner:  NLM     Status:  MEDLINE    
To test the denervation of paraspinal muscles and further investigate the pathogenesis of scoliosis associated with syringomyelia via detecting the spread of acetylcholine receptor (AChR) beyond the confines of the functional neuromuscular junction. Patients were divided into three groups: Group A consisted of 25 patients with scoliosis associated with syringomyelia, Group B included 16 adolescents with idiopathic scoliosis, and Group C comprised 10 cases without scoliosis. Bilateral biopsy of paraspinal muscles was performed during scheduled spinal surgery. Histological evaluation used a double-stain immunofluorescence technique for AchR and acetylcholinesterase. Histological analysis showed that 14 of 25 patients in Group A scored positive for the presence of AchR outside of the neuromuscular junction. There was no significant difference of the positive rate between patients with different degrees of cerebellar tonsillar descent, between patients with distended and non-distended syrinx, with syringx length <or=10 vertebral bodies and >10 vertebral bodies, and with Cobb angle <or=45 degrees and >45 degrees (p>0.05). The denervation of paraspinal muscles is present in some patients with scoliosis associated with syringomyelia, suggesting that scoliosis may be caused by a strength imbalance of paraspinal muscles in these patients.
Yong Qiu; Zezhang Zhu; Bin Wang; Yang Yu
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Studies in health technology and informatics     Volume:  123     ISSN:  0926-9630     ISO Abbreviation:  Stud Health Technol Inform     Publication Date:  2006  
Date Detail:
Created Date:  2006-11-19     Completed Date:  2007-01-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214582     Medline TA:  Stud Health Technol Inform     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  117-22     Citation Subset:  T    
Spine Surgery, Drum Tower Hospital, Nanjing University Medical School, Nanjing, 210008, China.
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MeSH Terms
Fluorescent Antibody Technique
Muscle, Skeletal / innervation*
Receptors, Cholinergic / analysis*
Scoliosis / pathology*
Syringomyelia / pathology*
Reg. No./Substance:
0/Receptors, Cholinergic

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