| Abnormal serum immunoglobulin levels in Down's syndrome patients. | |
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MedLine Citation:
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PMID: 150229 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serum immunoglobulin levels were measured in 20 patients with Down's syndrome and 16 mentally retarded cerebral palsy control patients. Significant elevation of IgG and IgD levels were found in the Down's syndrome as compared with the control patients. Serum IgD level in Down's syndrome individuals significantly decreased with increasing age. Serum IgA level was significantly elevated in older Down's syndrome patients but showed no change in younger Down's syndrome patients. Serum IgM and IgE levels were slightly elevated in Down's syndrome patients, but these differences were not significant. The elevated immunoglobulin levels in Down's syndrome individuals seem to be a response to increased frequency of infection. |
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Authors:
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Y Nishida; Y Sano; I Akaoka; M Maruki; T Suzuki; K Maruki |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: American journal of mental deficiency Volume: 83 ISSN: 0002-9351 ISO Abbreviation: Am J Ment Defic Publication Date: 1978 Jul |
Date Detail:
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Created Date: 1978-09-15 Completed Date: 1978-09-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372647 Medline TA: Am J Ment Defic Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 16-20 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Cerebral Palsy / immunology Child Down Syndrome / immunology* Female Humans Immunoglobulin A / analysis Immunoglobulin D / analysis Immunoglobulin E / analysis Immunoglobulin G / analysis Immunoglobulin M / analysis Immunoglobulins / analysis* Male Mental Retardation / immunology |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin A; 0/Immunoglobulin D; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Immunoglobulins; 37341-29-0/Immunoglobulin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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