| Abnormal resting-state functional connectivity of posterior cingulate cortex in amnestic type mild cognitive impairment. | |
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MedLine Citation:
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PMID: 19765560 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Amnestic type mild cognitive impairment (aMCI) refers to a transitional stage between normal aging and Alzheimer's disease (AD). Whilst posterior cingulate cortex (PCC) is believed to have a key role in a default network and be involved in the pathophysiology of AD, few studies have investigated whole-brain functional connectivity of PCC during resting state, or investigated the relationship between abnormal functional connectivity and disturbance in cognitive function in aMCI patients. Resting-state functional connectivity analysis was used to examine the temporal correlation between PCC and whole-brain regions in 30 aMCI patients and 26 well-matched controls. Further analysis involved evaluation of possible relationships between functional connectivity measures and cognitive function. Regions of decreased functional connectivity were identified in aMCI patients, most notably in temporal cortex, whilst significantly increased functional connectivity was mainly in frontal cortex. In addition, functional connectivity of PCC and temporal cortex was associated with the performance of neuropsychological tests in aMCI patients. This would be consonant with the recruitment of compensatory mechanisms and the process of offset functional impairments appearing as neuropathologic develops, and resting-state connectivity disturbance of PCC-temporal cortex may be a central role in cognitive deficit in aMCI patients. |
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Authors:
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Feng Bai; David R Watson; Hui Yu; Yongmei Shi; Yonggui Yuan; Zhijun Zhang |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-16 |
Journal Detail:
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Title: Brain research Volume: 1302 ISSN: 1872-6240 ISO Abbreviation: Brain Res. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-06 Completed Date: 2010-02-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 167-74 Citation Subset: IM |
Affiliation:
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School of Clinical Medicine, Southeast University, Nanjing, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Amnesia / pathology, physiopathology* Brain Mapping Cognition Disorders / pathology, physiopathology* Disability Evaluation Female Frontal Lobe / anatomy & histology, physiopathology Functional Laterality / physiology Gyrus Cinguli / pathology, physiopathology* Humans Magnetic Resonance Imaging Male Nerve Net / pathology, physiopathology* Neural Pathways / pathology, physiopathology Neuropsychological Tests Temporal Lobe / anatomy & histology, physiopathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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