Document Detail

Abnormal renal function in isolated systolic hypertension correlation with ambulatory blood pressure.
MedLine Citation:
PMID:  8225675     Owner:  NLM     Status:  MEDLINE    
Does ambulatory blood pressure correlate with the renal function damage better than clinic blood pressure in isolated systolic hypertension, as has been reported in other target organ involvement in combined systolic/diastolic hypertension? We investigated the correlation of serum beta-2 microglobulin concentration and both 24-h urine beta-2 microglobulin concentration and excretion as measures (suggestive) of glomerular filtration rate and tubular reabsorption, respectively with both ambulatory and clinic blood pressure in 19 health normotensive (68 +/- 4.9 years) and 50 isolated systolic hypertensive elderly individuals (69 +/- 5.4 years). Serum beta-2 microglobulin concentration and 24-h urine beta-2 microglobulin concentration and excretion were higher in the isolated systolic hypertension than in the normotensive group (P < 0.05). In isolated systolic hypertensive patients, 24-h urine beta-2 microglobulin concentration and excretion were related to ambulatory blood pressure (r = 0.32-0.40, P < 0.05), but not to clinic blood pressure; waking systolic blood pressure had the strongest correlation with both 24-h urine beta-2 microglobulin concentration and excretion among derivatives of ambulatory blood pressure (r = 0.35 and 0.40, P < 0.05). We conclude that ambulatory blood pressure, especially waking systolic blood pressure, is superior to clinical blood pressure in predicting renal function impairment, in isolated systolic hypertensive patients.
J Ming; L L Sheng; L G Zhang; Q D Ren; C Xueyan; Z J Fen; F S Ru; W S Ling
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  International journal of cardiology     Volume:  41     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-12-22     Completed Date:  1993-12-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  69-75     Citation Subset:  IM    
Hypertension Division, Fu Wai Hospital, Beijing, China.
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MeSH Terms
Blood Pressure
Blood Pressure Determination
Blood Pressure Monitors
Glomerular Filtration Rate
Hypertension / blood,  complications,  physiopathology*,  urine
Kidney Diseases / blood,  complications,  physiopathology*,  urine
Middle Aged
Regression Analysis
beta 2-Microglobulin / analysis
Reg. No./Substance:
0/beta 2-Microglobulin

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