Document Detail

Abnormal regulation for progesterone production in placenta with prenatal cocaine exposure in rats.
MedLine Citation:
PMID:  23103204     Owner:  NLM     Status:  Publisher    
Cocaine abuse in pregnant women is currently a significant public hygiene problem and is tightly associated with elevated risk for preterm delivery. Placental steroidogenesis especially progesterone production was essential for success and maintenance of pregnancy in humans and rodents. In the present study, we determined the impact of prenatal cocaine exposure on pathways of placental progesterone synthesis in rats. Pregnant rats were treated cocaine twice daily (15 mg/kg/day) during the third trimester, and the maternal and fetal plasma progesterone and pregnenolone concentrations were detected. We also examined both the protein and mRNA expression of some key enzymes and regulators for progesterone production in placenta. Results showed that, after maternal cocaine use during pregnancy, progesterone and pregnenolone concentrations in both maternal and fetal rats were significantly decreased. Although prenatal cocaine exposure had no effects on placental 3β-hydroxysteroid dehydrogenase type 1 (3βHSD1) expression, protein and mRNA expression of the cholesterol side-chain cleavage enzyme (P450scc/CYP11a) in placenta was significantly inhibited. Moreover, protein and mRNA expressions of MLN64 that regulating cholesterol transport and activating protein 2γ (AP2γ/Tfap2c) that controlling P450scc/CYP11a gene expression in placenta were both decreased following maternal cocaine use in pregnancy. Collectively, this study suggested that prenatal cocaine exposure could insult the placental progesterone production in rats possibly associated with the high risk for preterm delivery.
L Wu; J Yan; S C Qu; Y Q Feng; X L Jiang
Related Documents :
8033524 - Increases in serum lipids during pregnancy in type 1 diabetic women with nephropathy.
19024174 - Clinical laboratory values during diabetic pregnancies.
7025884 - Haemoglobin aic predicts the perinatal outcome in insulin-dependent diabetic pregnancies.
23998044 - Frequency of foetal anomalies in a tertiary care centre.
24741124 - High-intensity focused ultrasound ablation of uterine fibroids - potential impact on fe...
7944774 - Home heparin therapy used in a pregnant patient with a mechanical heart valve prosthesis.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-24
Journal Detail:
Title:  Placenta     Volume:  -     ISSN:  1532-3102     ISO Abbreviation:  Placenta     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Department of Maternal and Child Health Care, Centers for Disease Control and Prevention of Suzhou Industrial Park, Suzhou 215021, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Lesion of olfactory epithelium attenuates expression of morphine-induced behavioral sensitization an...
Next Document:  Enhanced xylitol production through simultaneous co-utilization of cellobiose and xylose by engineer...