| Abnormal production of tumor necrosis factor (TNF) -- alpha and clinical efficacy of the TNF inhibitor etanercept in a patient with PAPA syndrome [corrected] | |
MedLine Citation:
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PMID: 15580218 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a family with pyogenic sterile arthritis, pyoderna and acne syndrome (PAPA). The proband presented several episodes of sterile pyogenic arthritis and became unresponsive to glucocorticoids. After treatment with the tumor necrosis factor inhibitor etanercept, the disease underwent rapid and sustained clinical remission. Production of tumor necrosis factor-alpha by mononuclear cells of the proband and of the affected relatives was abnormally elevated. |
Authors:
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Elisabetta Cortis; Fabrizio De Benedetti; Antonella Insalaco; Stefania Cioschi; Flaminia Muratori; Leila E D'Urbano; Alberto G Ugazio |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Journal of pediatrics Volume: 145 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-12-06 Completed Date: 2005-01-06 Revised Date: 2005-02-18 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 851-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Division of Rheumathology and Laboratory of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acne Vulgaris
/
complications*,
drug therapy,
genetics Adaptor Proteins, Signal Transducing / genetics Adolescent Adult Anti-Inflammatory Agents, Non-Steroidal / therapeutic use* Arthritis / complications*, drug therapy, genetics Child Child, Preschool Cytoskeletal Proteins / genetics Female Humans Immunoglobulin G / therapeutic use* Male Pyoderma / complications*, drug therapy, genetics Receptors, Tumor Necrosis Factor / therapeutic use* Syndrome Tumor Necrosis Factor-alpha / antagonists & inhibitors*, biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Adaptor Proteins, Signal Transducing; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Cytoskeletal Proteins; 0/Immunoglobulin G; 0/PSTPIP1 protein, human; 0/Receptors, Tumor Necrosis Factor; 0/Tumor Necrosis Factor-alpha; 185243-69-0/TNFR-Fc fusion protein |
| Comments/Corrections | |
Erratum In:
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J Pediatr. 2005 Feb;146(2):193 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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