Document Detail

Abnormal pressure natriuresis. A cause or a consequence of hypertension?
MedLine Citation:
PMID:  1971810     Owner:  NLM     Status:  MEDLINE    
In all forms of chronic hypertension, the renal-pressure natriuresis mechanism is abnormal because sodium excretion is the same as in normotension despite the increased blood pressure. However, the importance of this resetting of pressure natriuresis as a cause of hypertension is controversial. Theoretically, a resetting of pressure natriuresis could necessitate increased blood pressure to maintain sodium balance or it could occur secondarily to hypertension. Recent studies indicate that, in several models of experimental hypertension (including angiotensin II, aldosterone, adrenocorticotrophic hormone, and norepinephrine hypertension), a primary shift of renal-pressure natriuresis necessitates increased arterial pressure to maintain sodium and water balance. In genetic animal models of hypertension, there also appears to be a resetting of pressure natriuresis before the development of hypertension. Likewise, essential hypertensive patients exhibit abnormal pressure natriuresis, although the precise cause of this defect is not clear. It is likely that multiple renal defects contribute to resetting of pressure natriuresis in essential hypertensive patients. With long-standing hypertension, pathological changes that occur secondary to hypertension must also be considered. By analyzing the characteristics of pressure natriuresis in hypertensive patients and by comparing these curves to those observed in various forms of experimental hypertension of known origin, it is possible to gain insight into the etiology of this disease.
J E Hall; H L Mizelle; D A Hildebrandt; M W Brands
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Hypertension     Volume:  15     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-07-06     Completed Date:  1990-07-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  547-59     Citation Subset:  IM    
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216-4505.
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MeSH Terms
Blood Pressure / drug effects
Hypertension / etiology*,  physiopathology
Kidney / physiopathology
Natriuresis / drug effects,  physiology*
Neurotransmitter Agents / physiology
Water-Electrolyte Balance / physiology
Grant Support
Reg. No./Substance:
0/Neurotransmitter Agents

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