| Abnormal pressure natriuresis. A cause or a consequence of hypertension? | |
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MedLine Citation:
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PMID: 1971810 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In all forms of chronic hypertension, the renal-pressure natriuresis mechanism is abnormal because sodium excretion is the same as in normotension despite the increased blood pressure. However, the importance of this resetting of pressure natriuresis as a cause of hypertension is controversial. Theoretically, a resetting of pressure natriuresis could necessitate increased blood pressure to maintain sodium balance or it could occur secondarily to hypertension. Recent studies indicate that, in several models of experimental hypertension (including angiotensin II, aldosterone, adrenocorticotrophic hormone, and norepinephrine hypertension), a primary shift of renal-pressure natriuresis necessitates increased arterial pressure to maintain sodium and water balance. In genetic animal models of hypertension, there also appears to be a resetting of pressure natriuresis before the development of hypertension. Likewise, essential hypertensive patients exhibit abnormal pressure natriuresis, although the precise cause of this defect is not clear. It is likely that multiple renal defects contribute to resetting of pressure natriuresis in essential hypertensive patients. With long-standing hypertension, pathological changes that occur secondary to hypertension must also be considered. By analyzing the characteristics of pressure natriuresis in hypertensive patients and by comparing these curves to those observed in various forms of experimental hypertension of known origin, it is possible to gain insight into the etiology of this disease. |
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Authors:
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J E Hall; H L Mizelle; D A Hildebrandt; M W Brands |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Hypertension Volume: 15 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1990 Jun |
Date Detail:
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Created Date: 1990-07-06 Completed Date: 1990-07-06 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 547-59 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216-4505. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Feedback Humans Hypertension / etiology*, physiopathology Kidney / physiopathology Natriuresis / drug effects, physiology* Neurotransmitter Agents / physiology Water-Electrolyte Balance / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL-11678/HL/NHLBI NIH HHS; HL-23502/HL/NHLBI NIH HHS; HL-39399/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Neurotransmitter Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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