| Abnormal predefecatory colonic motor patterns define constipation in obstructed defecation. | |
| | |
MedLine Citation:
|
PMID: 15236171 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND & AIMS: The pathophysiology of constipation in the syndrome of obstructed defecation is unknown. Using 24-hour pancolonic manometric recordings of the unprepared colon to record basal pressures and spontaneous defecation episodes, we tested the hypothesis that the frequency, timing, or spatial distribution of propagating colonic pressure waves is abnormal in patients with obstructed defecation. METHODS: In 11 patients with obstructed defecation and 16 healthy controls, pressures were recorded using a nasocolonic catheter that was positioned such that 16 recording sites spanned the unprepared colon at 7.5-cm intervals. RESULTS: The overall frequency of propagating sequences (PS) in the colon did not differ between patients and controls. When compared with controls, patients had a significant increase in the frequency of retrograde and antegrade PS (P < 0.05) in the left colon and a significant reduction in the amplitude of propagating pressure waves throughout the entire colon (P < 0.03). Defecation occurred in 6 of 11 patients and 9 of 16 controls. In the 15 minutes before defecation, controls showed a highly significant increase in frequency (P = 0.001) and amplitude (P = 0.01) of PS. In contrast, patients did not demonstrate this or the typical spatiotemporal organization of PS normally observed before expulsion of stool. CONCLUSIONS: Patients with obstructed defecation lack the normal predefecatory augmentation in frequency and amplitude of propagating pressure waves and lack the normal stereotypic spatiotemporal patterning of colonic pressure waves that would normally culminate in effective expulsion of stool. |
| | |
Authors:
|
Philip G Dinning; Peter A Bampton; Julie Andre; Michael L Kennedy; David Z Lubowski; Denis W King; Ian J Cook |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Gastroenterology Volume: 127 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 2004 Jul |
Date Detail:
|
Created Date: 2004-07-05 Completed Date: 2004-09-28 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: United States |
Other Details:
|
Languages: eng Pagination: 49-56 Citation Subset: AIM; IM |
Affiliation:
|
Department of Gastroenterology, The St. George Hospital, University of New South Wales, Kogarah, New South Wales, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Colonic Diseases, Functional / physiopathology* Constipation / physiopathology* Defecation / physiology* Defecography Female Gastrointestinal Motility / physiology* Humans Male Manometry Middle Aged |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Computed tomographic colonography compared with colonoscopy in patients at increased risk for colore...
Next Document: Laryngo-upper esophageal sphincter contractile reflex in humans deteriorates with age.