Document Detail


Abnormal pituitary-adrenal responses to corticotropin-releasing hormone in patients with seasonal affective disorder: clinical and pathophysiological implications.
MedLine Citation:
PMID:  1851185     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CRH has been shown to produce increased locomotion, arousal, and anorexia in experimental animals. A deficiency of CRH in patients with seasonal affective disorder could contribute to the characteristic lethargy, hypersomnia, and hyperphagia characteristic of this illness. To test this hypothesis, we studied basal plasma ACTH and cortisol levels and their responses to ovine CRH in controls and depressed patients with seasonal affective disorder before and after light treatment. Untreated seasonal affective disorder patients showed normal basal plasma cortisol and ACTH levels, but their responses to CRH tended to be delayed and were significantly reduced. When patients were studied after 9 days of light treatment, a significant increase in plasma ACTH and cortisol responses to CRH was observed. Our findings in untreated patients with seasonal affective disorder are similar to those in patients with Cushing's disease 2 weeks after transsphenoidal hypophysectomy, who uniformly show sustained suppression of their CRH neuron because of long-standing hypercortisolism. This findings suggest that the CRH neuron of patients with seasonal affective disorder is hypofunctional. We postulate that the clinical symptomatology in patients with seasonal affective disorder could reflect deficient activity of this important arousal-producing system.
Authors:
J R Joseph-Vanderpool; N E Rosenthal; G P Chrousos; T A Wehr; R Skwerer; S Kasper; P W Gold
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  72     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-06-13     Completed Date:  1991-06-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1382-7     Citation Subset:  AIM; IM    
Affiliation:
Clinical Psychobiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20009.
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MeSH Terms
Descriptor/Qualifier:
Adrenocorticotropic Hormone / blood
Adult
Animals
Circadian Rhythm
Corticotropin-Releasing Hormone / pharmacology*
Humans
Hydrocortisone / secretion
Longitudinal Studies
Middle Aged
Mood Disorders / metabolism,  physiopathology*,  therapy
Phototherapy
Pituitary-Adrenal System / drug effects*
Reference Values
Seasons
Sheep
Chemical
Reg. No./Substance:
50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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