| Abnormal patterns of colorectal mucin secretion after urinary diversion of different types: histochemical and lectin binding studies. | |
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MedLine Citation:
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PMID: 3089901 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clinical and experimental evidence indicates that ureterosigmoidostomy is associated with a high risk for the development of colonic cancer, while there is no reported evidence of increased risk in patients who undergo urinary diversion of other types. In the present study the histochemical and lectin binding characteristics of goblet cell mucin were investigated in biopsy specimens from patients who had undergone ureterosigmoidostomy and from patients who had undergone rectal bladder surgery. Specimens from transitional mucosa surrounding colonic cancers and from normal rectal mucosa were also studied. For histochemical studies the high iron diamine-Alcian blue method was used. FITC-conjugated Dolichus biflorus agglutinin (FITC-DBA) and Arachis hypogaea agglutinin (FITC-PNA) were used for the study of lectin binding characteristics. In contrast to the striking increase in numbers of sialomucin-containing goblet cells found in the patients who had undergone ureterosigmoidostomy, the mucin proved to be histochemically normal in the rectal bladder surgery group. Abnormal lectin binding patterns were observed in colorectal mucosa after urinary diversion of both types, with the abnormalities consisting of dramatic decreases in FITC-DBA labeling (compared with controls) and the appearance of substantial numbers of FITC-PNA-labeled goblet cells. These findings indicate that the pattern of mucin secretion is definitely abnormal in patients who have undergone urinary diversion. Whether this abnormality is an indicator of premalignant changes remains to be established. These data, however, confirm that endoscopic and histologic follow-up studies may be of value in assessing the risk for the development of cancer in these patients. |
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Authors:
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C Iannoni; A Marcheggiano; F Pallone; G Frieri; M Gallucci; F Di Silverio; R Caprilli |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Human pathology Volume: 17 ISSN: 0046-8177 ISO Abbreviation: Hum. Pathol. Publication Date: 1986 Aug |
Date Detail:
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Created Date: 1986-09-17 Completed Date: 1986-09-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9421547 Medline TA: Hum Pathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 834-40 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Colon / secretion Colon, Sigmoid / surgery Female Fluorescein-5-isothiocyanate Fluoresceins / diagnostic use Histocytochemistry Humans Intestinal Mucosa / secretion* Lectins / diagnostic use Male Microscopy, Fluorescence Middle Aged Mucins / secretion* Peanut Agglutinin Plant Lectins* Rectum / secretion, surgery Thiocyanates / diagnostic use Urinary Diversion / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Fluoresceins; 0/Lectins; 0/Mucins; 0/Peanut Agglutinin; 0/Plant Lectins; 0/Thiocyanates; 0/dolichos biflorus agglutinin; 3326-32-7/Fluorescein-5-isothiocyanate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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