Document Detail

Abnormal monocyte function in bladder cancer patients.
MedLine Citation:
PMID:  1271545     Owner:  NLM     Status:  MEDLINE    
We evaluated 39 patients with various stages of bladder carcinoma to determine alterations in monocyte function. Since the monocyte plays an important role in the effector arm of the immune system defective function may explain the host's inability to destroy neoplastic cells. As a group these 39 patients demonstrated defective monocyte monocyte function. There was no correlation between tumor stage and degree of chemotactic defect. Patients with invasive carcinoma had a significant return of monocyte chemotactic response toward normal postoperatively (p less than 0.005). Monocyte function was improved also in 3 patients who received Bacillus Calmette-Guerin immunotherapy (p less than 0.05).
M S Hausman; S A Brosman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of urology     Volume:  115     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  1976 May 
Date Detail:
Created Date:  1976-08-02     Completed Date:  1976-08-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  537-41     Citation Subset:  AIM; IM    
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MeSH Terms
BCG Vaccine / therapeutic use
Immunity, Cellular
Monocytes / immunology*,  pathology
Urinary Bladder Diseases / immunology
Urinary Bladder Neoplasms / immunology*,  pathology,  surgery,  therapy
Reg. No./Substance:
0/BCG Vaccine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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