| Abnormal mitochondrial dynamics and neurodegenerative diseases. | |
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MedLine Citation:
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PMID: 19799998 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mitochondrial dysfunction is a prominent feature of various neurodegenerative diseases. A deeper understanding of the remarkably dynamic nature of mitochondria, characterized by a delicate balance of fission and fusion, has helped to fertilize a recent wave of new studies demonstrating abnormal mitochondrial dynamics in neurodegenerative diseases. This review highlights mitochondrial dysfunction and abnormal mitochondrial dynamics in Alzheimer disease, Parkinson disease, amyotrophic lateral sclerosis, and Huntington disease and discusses how these abnormal mitochondrial dynamics may contribute to mitochondrial and neuronal dysfunction. We propose that abnormal mitochondrial dynamics represents a key common pathway that mediates or amplifies mitochondrial dysfunction and neuronal dysfunction during the course of neurodegeneration. |
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Authors:
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Bo Su; Xinglong Wang; Ling Zheng; George Perry; Mark A Smith; Xiongwei Zhu |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2009-09-30 |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1802 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-08 Completed Date: 2010-06-16 Revised Date: 2011-07-19 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 135-42 Citation Subset: IM |
Affiliation:
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Department of Pathology, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH 44106, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease
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metabolism Animals Humans Mitochondria / metabolism* Neurodegenerative Diseases / metabolism*, physiopathology Parkinson Disease / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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AG031852/AG/NIA NIH HHS; R01 AG031852-02/AG/NIA NIH HHS; R01 AG031852-04/AG/NIA NIH HHS |
| Comments/Corrections | |
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