Document Detail


Abnormal maxillary trapezoid pattern in human fetal cleft lip and palate.
MedLine Citation:
PMID:  18333644     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To elucidate abnormal growth patterns of human fetal maxillae with cleft lip and palate (CLP). SUBJECT: A total of 71 fetal maxillae with CLP were obtained from aborted human fetuses. METHOD: Dimensions of the maxillary trapezoid (MT), formed by the maxillary primary growth centers (MxPGC), were taken from radiographic images. The CLP dimensions were compared with maxillary trapezoid dimensions of normal fetuses from a previous study (Lee et al., 1992). MAIN OUTCOME MEASURES: Cleft lip subjects without a cleft palate, unilateral cleft lip-alveolar cleft or cleft palate (UCL+A/UCLP), and bilateral cleft lip-alveolar cleft or cleft palate (BCL+A/BCLP) displayed abnormal MT patterns. MT abnormalities were most marked in the BCL+A/BCLP cohort. RESULTS: The MT growth of prenatal CLP maxillae was severely arrested, resulting in abnormal MT shape on palatal radiograms. BCL+A/BCLP subjects had a more protruded nasal septum than subjects with other types of CLPs, while UCL+A/UCLP subjects showed severe deviation of the protruded nasal septum toward the noncleft side. Cleft lip-only subjects also exhibited abnormal MT growth. CONCLUSION: MT is primarily involved in CLPs, so that the MT shape could be utilized as a sensitive indicator for the analysis of maxillary malformation in different types of CLPs.
Authors:
Soung Min Kim; Young Joon Lee; Sang Shin Lee; Yeon Sook Kim; Suk Keun Lee; Il Bong Kim; Je Geun Chi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association     Volume:  45     ISSN:  1055-6656     ISO Abbreviation:  Cleft Palate Craniofac. J.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-12     Completed Date:  2008-06-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102566     Medline TA:  Cleft Palate Craniofac J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  131-40     Citation Subset:  D; IM    
Affiliation:
Department of Oral and Maxillofacial Surgery, Kangnung National University, Gangeung, Korea.
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MeSH Terms
Descriptor/Qualifier:
Alveolar Process / abnormalities,  embryology
Case-Control Studies
Cephalometry / methods
Cleft Lip / embryology*
Cleft Palate / embryology*
Cohort Studies
Gestational Age
Humans
Maxilla / abnormalities*,  embryology
Nasal Bone / embryology
Nasal Septum / embryology
Sphenoid Bone / embryology
Zygoma / embryology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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