Document Detail

Abnormal lymph drainage in patients with chronic venous leg ulcers.
MedLine Citation:
PMID:  8463459     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Edema often occurs in association with venous leg ulcers. OBJECTIVE: Our purpose was to assess lymphatic function in the legs of patients with venous leg ulcers. METHODS: Quantitative lymphoscintigraphy was performed in 22 normal control subjects, 32 patients with venous leg ulcers, and 7 patients with varicose veins only. RESULTS: Lymph drainage declined with age in the normal controls (r = -0.57; p = 0.0001). Lymphatic function was reduced in the ulcerated legs compared with normal limbs (age < 65 years; p < 0.0001) and in edematous legs compared with nonedematous legs (age > 65 years; ulcerated legs, p = 0.016; nonulcerated legs, p = 0.021). Lymph drainage was lower in the legs of patients with varicose veins only (p = 0.004). CONCLUSION: Impaired lymphatic function is associated with both venous leg ulcers and chronic venous hypertension.
R H Bull; J N Gane; J E Evans; A E Joseph; P S Mortimer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  28     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-04-30     Completed Date:  1993-04-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  585-90     Citation Subset:  IM    
Department of Dermatology, St George's Hospital, London, England.
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MeSH Terms
Chronic Disease
Leg / physiopathology,  radionuclide imaging
Lymph Nodes / physiopathology,  radionuclide imaging
Lymphatic System / physiopathology*,  radionuclide imaging
Lymphedema / physiopathology,  radionuclide imaging
Middle Aged
Varicose Ulcer / physiopathology*,  radionuclide imaging
Venous Insufficiency / physiopathology,  radionuclide imaging

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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