Document Detail

Abnormal lipid profile and hyperinsulinaemia after a mixed meal: additional cardiovascular risk factors in young adults born preterm.
MedLine Citation:
PMID:  18496668     Owner:  NLM     Status:  MEDLINE    
AIMS/HYPOTHESIS: Low birthweight in infants born at term is related to the presence of the metabolic syndrome as an adult. Individuals born preterm invariably have low birthweights and may develop the metabolic syndrome as well. Although high BP, glucose intolerance and insulin resistance have been documented, dyslipidaemia has never been reported in individuals born preterm. METHODS: In three groups of young adults [29 participants from the POPS (Project On Premature and Small for Gestational Age Infants) cohort born preterm appropriate for gestational age (POPS-AGA), 28 participants from the POPS cohort born preterm small for gestational age (POPS-SGA) and 30 individuals born at term with normal birthweight (CON)] we investigated fasting lipids as well as postprandial responses during a mixed meal test. The relationship between fasting and postprandial measurements and insulin sensitivity, measured by the hyperinsulinaemic clamp, was investigated. RESULTS: Preterm participants had higher BP than CON individuals. Postprandial triacylglycerol levels were increased in POPS-SGA men. POPS-SGA individuals were hyperinsulinaemic during the mixed meal test. CONCLUSIONS/INTERPRETATION: The mixed meal test provides additional information on cardiovascular risk factors. Postprandial triacylglycerol levels are increased in POPS-SGA men. Postprandial hyperinsulinaemia is found in POPS-SGA individuals.
J Rotteveel; M M van Weissenbruch; J W R Twisk; H A Delemarre-Van de Waal
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Publication Detail:
Type:  Journal Article     Date:  2008-05-22
Journal Detail:
Title:  Diabetologia     Volume:  51     ISSN:  0012-186X     ISO Abbreviation:  Diabetologia     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-03     Completed Date:  2008-10-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0006777     Medline TA:  Diabetologia     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1269-75     Citation Subset:  IM    
Department of Pediatrics, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands.
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MeSH Terms
Blood Glucose / metabolism
Cardiovascular Diseases / epidemiology*,  metabolism*
Eating / physiology
Fatty Acids, Nonesterified / blood
Hyperinsulinism / epidemiology*,  metabolism*
Infant, Newborn
Infant, Premature*
Insulin / blood
Insulin Resistance / physiology
Metabolic Syndrome X / epidemiology,  metabolism
Postprandial Period / physiology
Risk Factors
Sex Distribution
Triglycerides / blood
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Triglycerides; 11061-68-0/Insulin

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