Document Detail

Abnormal levels of cAMP-dependent protein kinase regulatory subunits in platelets from schizophrenic patients.
MedLine Citation:
PMID:  10882848     Owner:  NLM     Status:  MEDLINE    
Abnormalities in the cAMP-dependent protein kinase (PKA), a central component of cAMP signaling, have been reported in several psychiatric disorders. Previous studies showed cAMP signaling alterations in schizophrenic patients but less is known about the involvement of PKA in such disorder. Therefore, we investigated the PKA subunits by Western blot analysis in platelets from 12 patients with schizophrenia and 13 controls. The results showed that the immunolabeling of the PKA regulatory subunits type I (RI) and type II (RII) was significantly reduced in patients compared with controls whereas no differences were observed in the catalytic (C) subunit of the enzyme. These preliminary data suggest that schizophrenic patients have altered PKA levels, thus supporting that dysfunctions in the components of cAMP signaling may contribute to the pathophysiology of schizophrenia.
D Tardito; G B Tura; L Bocchio; S Bignotti; R Pioli; G Racagni; J Perez
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology     Volume:  23     ISSN:  0893-133X     ISO Abbreviation:  Neuropsychopharmacology     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-09-06     Completed Date:  2000-09-06     Revised Date:  2011-05-18    
Medline Journal Info:
Nlm Unique ID:  8904907     Medline TA:  Neuropsychopharmacology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  216-9     Citation Subset:  IM    
Center of Neuropharmacology, Institute of Pharmacological Sciences, University of Milan, Milan, Italy.
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MeSH Terms
Actins / blood
Blood Platelets / enzymology*
Cyclic AMP-Dependent Protein Kinase Type II
Cyclic AMP-Dependent Protein Kinases / blood*
Schizophrenia / blood,  enzymology*
Reg. No./Substance:
0/Actins; EC AMP-Dependent Protein Kinase Type II; EC AMP-Dependent Protein Kinases

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