Document Detail


Abnormal left ventricular systolic and diastolic functional response to isometric exercise in idiopathic dilated cardiomyopathy: beneficial effect of captopril.
MedLine Citation:
PMID:  8745586     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In 19 patients with idiopathic dilated cardiomyopathy and symptoms of congestive heart failure, left ventricular (LV) systolic performance and diastolic velocity profiles were assessed by two- dimensional echocardiography and pulsed wave Doppler at rest and during handgrip exercise before and ninety minutes after administration of captopril (mean dose 25 +/- 12mg; range 12.5-50mg). Although heart rate and blood pressure increased similarly during handgrip exercise before and after captopril treatment, both were lower with handgrip exercise during captopril treatment. The results from this study indicated that acute angiotension converting enzyme inhibition with captopril reduces preload and afterload and ameliorates handgrip exercise-induced LV systolic and diastolic filling dysfunction in patients with congestive heart failure secondary to idiopathic dilated cardiomyopathy.
Authors:
W Shen; X Zhang; H Hu; L Gong
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chinese medical sciences journal = Chung-kuo i hsüeh k'o hsüeh tsa chih / Chinese Academy of Medical Sciences     Volume:  10     ISSN:  1001-9294     ISO Abbreviation:  Chin. Med. Sci. J.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-12-05     Completed Date:  1996-12-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9112559     Medline TA:  Chin Med Sci J     Country:  CHINA    
Other Details:
Languages:  eng     Pagination:  232-6     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Shanghai Second Medical University.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Angiotensin-Converting Enzyme Inhibitors / pharmacology,  therapeutic use*
Blood Pressure / drug effects
Captopril / pharmacology,  therapeutic use*
Cardiomyopathy, Dilated / complications,  physiopathology*,  ultrasonography
Echocardiography, Doppler, Pulsed
Exercise
Female
Heart Failure / etiology,  physiopathology,  ultrasonography
Heart Rate / drug effects
Humans
Male
Middle Aged
Systole / drug effects
Ventricular Function, Left / drug effects*
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 62571-86-2/Captopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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