| Abnormal left ventricular function occurs on exercise in well-treated hypertensive subjects with normal resting echocardiography. | |
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MedLine Citation:
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PMID: 20538670 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: This study tests the hypothesis that patients with treated hypertension with well-controlled blood pressure, without ventricular hypertrophy and normal resting echocardiography, may have abnormalities of ventricular function that are apparent only on exercise and contribute to symptoms of exertional dyspnoea. METHODS: Patients with hypertension with well-controlled blood pressure on medication and normal baseline echocardiography underwent cardiopulmonary exercise testing to determine their peak oxygen consumption (Vo(2)(max)), followed by rest and submaxinal supine exercise echocardiography (standard, tissue Doppler and speckle tracking). RESULTS: 30 patients with treated hypertension with a history of exertional dyspnoea (mean age 71+/-8 years; 18 women) and 22 age-matched healthy controls (70+/-6 years; 16 women) had rest and exercise images of sufficient quality for analysis. Both groups had comparable standard echocardiographic findings at rest. On exercise, the patients had reduced systolic longitudinal function (reserve index 0.97+/-1.34 vs 2.32+/-1.24, p=0.001), delayed early untwisting (20.4+/-7.6 vs 30.6+/-7.8%, p=0.001) and reduced ventricular suction (velocity propagation 10.6+/-10.9 vs 24.5+/-12.2 m/s, p<0.001) compared with healthy controls, which correlated with significantly reduced Vo(2)(max). CONCLUSION: Patients with treated hypertension with normal resting echocardiography can have exercise limitation associated with widespread systolic and diastolic left ventricular dysfunction on exercise. Normal resting echocardiography does not preclude the presence of significant functional abnormalities on exercise that can contribute to symptoms. |
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Authors:
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Yu Ting Tan; Frauke Wenzelburger; Eveline Lee; Grant Heatlie; Michael Frenneaux; John E Sanderson |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Heart (British Cardiac Society) Volume: 96 ISSN: 1468-201X ISO Abbreviation: Heart Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-11 Completed Date: 2010-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9602087 Medline TA: Heart Country: England |
Other Details:
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Languages: eng Pagination: 948-55 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Dyspnea / etiology, physiopathology Echocardiography, Doppler / methods Exercise / physiology* Exercise Test / methods False Negative Reactions Female Humans Hypertension / complications*, drug therapy, physiopathology Male Observer Variation Oxygen Consumption / physiology Reproducibility of Results Rotation Ventricular Dysfunction, Left / etiology*, physiopathology, ultrasonography |
| Grant Support | |
ID/Acronym/Agency:
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PG/06/106/21472//British Heart Foundation |
| Comments/Corrections | |
Comment In:
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Heart. 2010 Jun;96(12):906-7
[PMID:
20538663
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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