Document Detail

Abnormal laterality and congenital cardiac anomalies. Relations of visceral and cardiac morphologies in the iv/iv mouse.
MedLine Citation:
PMID:  1638728     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In the management of hearts with deranged laterality, it is essential that the left and right atrial chambers are correctly identified. There are two major approaches, which are based on venous connections or on the morphology of the atrial appendages, and there is no consensus as to which is the most useful. We used the iv/iv mouse mutant, which is known to be pertinent to this problem, to evaluate the relations of cardiac defects with atrial, venous, and other visceral morphologies. METHODS AND RESULTS: The morphology of the heart and other organs was examined in 275 iv/iv mice using criteria based on abnormal laterality in humans. The arrangement of the atrial appendages was determined by morphological examination of the junction between the appendage and the venous component of the atrium. On this basis, 45.1% of cases were shown to have usual atrial arrangement, 50.2% had mirror imagery, 1.5% had right isomerism, and 3.3% had left isomerism. Every case of atrial isomerism had a cardiac lesion; the morphological types were similar to those seen in human cases. Of cases with either usual or mirror-image arrangement of the appendages, 33.2% had abnormal spleens, but only 3.1% had cardiac defects. Similarly, venous abnormalities were much more common (30.1%) than cardiac defects. CONCLUSIONS: Study results endorse the importance of the morphology of atrial appendages in predicting cardiac abnormalities and point to the marked inconsistency of the arrangement of other organs, including the spleen and the connections of the systemic veins.
J W Seo; N A Brown; S Y Ho; R H Anderson
Related Documents :
10520768 - Catheter ablation of atrial flutter.
6214528 - Myocardial cell heterogeneity in the human heart with respect to myosin atpase activity.
3304698 - Transitions in cardiac isomyosin expression during differentiation of the embryonic chi...
11520448 - Management of atrial flutter.
17673878 - Loop diuretic therapy, thiamine balance, and heart failure.
17075718 - Why are mineralocorticoid receptor antagonists cardioprotective?
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation     Volume:  86     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-09-03     Completed Date:  1992-09-03     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  642-50     Citation Subset:  AIM; IM    
Department of Paediatrics, National Heart and Lung Institute, London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arteriovenous Malformations / pathology
Heart Atria / abnormalities
Heart Defects, Congenital / classification,  pathology*
Liver / abnormalities
Lung / abnormalities
Mice, Mutant Strains
Situs Inversus / pathology*
Spleen / abnormalities

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Mechanism of double potentials recorded during sustained atrial flutter in the canine right atrial c...
Next Document:  Influence of loading conditions and contractile state on pulmonary venous flow. Validation of Dopple...