| Abnormal iodine-123-MIBG images in healthy volunteers. | |
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MedLine Citation:
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PMID: 8862311 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have encountered two healthy volunteers with significant reductions of myocardial [123I]MIBG (metaiodobenzylguanidine) uptake and rapid clearance. In one of these subjects (a 31-yr-old man), we performed additional examinations to clarify the mechanism of the abnormal myocardial MIBG uptake. There was no abnormality on orthostatic test, maximal exercise test (bicycle ergometer) or in plasma norepinephrine concentration. Nevertheless, power spectral analysis (PSA) of heart rate variability revealed that the percent low frequency component (%LF), an index of sympathetic nerve activity, was increased. Furthermore, [123I]MIBG scintigraphy after oral administration of an alpha 2 agonist (guanabenz acetate; 4 mg) demonstrated that myocardial uptake and clearance of MIBG returned to normal, as did the %LF. These results suggest that reduced uptake and rapid clearance of myocardial MIBG in this subject was strongly related to the increased release of norepinephrine from sympathetic nerve terminals due to augmented sympathetic activity. This subject illustrated that unsuspected, subclinical variants of normal or abnormal sympathetic functions may pose a diagnostic pitfall in interpretating myocardial MIBG images. |
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Authors:
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T Morozumi; K Fukuchi; T Uehara; H Kusuoka; M Hori; T Nishimura |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 37 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 1996 Oct |
Date Detail:
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Created Date: 1996-11-13 Completed Date: 1996-11-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1686-8 Citation Subset: IM |
Affiliation:
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First Department of Medicine, Osaka University Medical School, Suita, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3-Iodobenzylguanidine Adult Heart / innervation, radionuclide imaging* Humans Iodine Radioisotopes / diagnostic use* Iodobenzenes / diagnostic use* Male Sympathetic Nervous System / physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Iodine Radioisotopes; 0/Iodobenzenes; 77679-27-7/3-Iodobenzylguanidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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