Document Detail

Abnormal iodine-123-MIBG images in healthy volunteers.
MedLine Citation:
PMID:  8862311     Owner:  NLM     Status:  MEDLINE    
We have encountered two healthy volunteers with significant reductions of myocardial [123I]MIBG (metaiodobenzylguanidine) uptake and rapid clearance. In one of these subjects (a 31-yr-old man), we performed additional examinations to clarify the mechanism of the abnormal myocardial MIBG uptake. There was no abnormality on orthostatic test, maximal exercise test (bicycle ergometer) or in plasma norepinephrine concentration. Nevertheless, power spectral analysis (PSA) of heart rate variability revealed that the percent low frequency component (%LF), an index of sympathetic nerve activity, was increased. Furthermore, [123I]MIBG scintigraphy after oral administration of an alpha 2 agonist (guanabenz acetate; 4 mg) demonstrated that myocardial uptake and clearance of MIBG returned to normal, as did the %LF. These results suggest that reduced uptake and rapid clearance of myocardial MIBG in this subject was strongly related to the increased release of norepinephrine from sympathetic nerve terminals due to augmented sympathetic activity. This subject illustrated that unsuspected, subclinical variants of normal or abnormal sympathetic functions may pose a diagnostic pitfall in interpretating myocardial MIBG images.
T Morozumi; K Fukuchi; T Uehara; H Kusuoka; M Hori; T Nishimura
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  37     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1996-11-13     Completed Date:  1996-11-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1686-8     Citation Subset:  IM    
First Department of Medicine, Osaka University Medical School, Suita, Japan.
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MeSH Terms
Heart / innervation,  radionuclide imaging*
Iodine Radioisotopes / diagnostic use*
Iodobenzenes / diagnostic use*
Sympathetic Nervous System / physiopathology
Reg. No./Substance:
0/Iodine Radioisotopes; 0/Iodobenzenes; 77679-27-7/3-Iodobenzylguanidine

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