Document Detail


Abnormal intestinal histology in neonates with congenital anomalies of the gastrointestinal tract.
MedLine Citation:
PMID:  14646337     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In animal models, when swallowing is experimentally prevented in utero, bowel length and weight are reduced, and villus height, crypt depth, and villus function are retarded. Little is known about the intestinal histology in infants with gastrointestinal (GI) tract anomalies. We examined the histological architecture of the intestine in neonates with GI anomalies in comparison to that of normal fetuses. Villus height, area, and length and crypt depth of normal fetuses were quantified in the proximal small bowel (n = 11) and measurements compared to those of surgical specimens of neonates with congenital anomalies of the GI tract (n = 16). Villus height and area and lamina propria height and area increased linearly from 8 to 24 weeks of gestation. In infants with anomalies of the GI tract, the villi were blunted and lacked normal histological architecture, the crypts were disorganized, and the crypt depth was significantly decreased (p = 0.004). Enterocyte height and area were significantly greater in neonates with congenital anomalies of the GI tract. The intestinal histology in neonates with congenital anomalies of the GI tract differs significantly from that of normal fetuses.
Authors:
Adria A Condino; Aaron A Barleycorn; Wenge Lu; Akhil Maheshwari; Robert D Christensen; Darlene A Calhoun
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2003-11-25
Journal Detail:
Title:  Biology of the neonate     Volume:  85     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  2004  
Date Detail:
Created Date:  2004-03-30     Completed Date:  2004-10-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  145-50     Citation Subset:  IM    
Copyright Information:
Copyright 2004 S. Karger AG, Basel
Affiliation:
Department of Pediatrics, The Children's Hospital, University of Colorado Health Science Center, Denver, CO, USA.
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MeSH Terms
Descriptor/Qualifier:
Embryonic and Fetal Development
Gastrointestinal Diseases / congenital*,  pathology
Humans
Immunohistochemistry
Infant, Newborn
Intestinal Mucosa / pathology*
Intestine, Small / abnormalities*,  pathology
Proliferating Cell Nuclear Antigen / metabolism
Grant Support
ID/Acronym/Agency:
HD-01180/HD/NICHD NIH HHS; HD-42326/HD/NICHD NIH HHS; HL-61798/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Proliferating Cell Nuclear Antigen

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