Document Detail


Abnormal interaction of the human apolipoprotein A-I variant [Lys107----0] with high density lipoproteins.
MedLine Citation:
PMID:  3936504     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several isoforms of apoprotein A-I [apoA-I], the major apoprotein of high density lipoproteins [HDL], have been described. We compared the in vivo and in vitro properties of normal human apoA-I with those of apoA-I [Lys107----0]. Fluorescence and circular dichroic spectra showed that deletion of Lys107 decreases apoprotein self-association. In vivo metabolic studies in the rat indicated that the interaction of apoA-I [Lys107----0] with HDL was lower than normal. We conclude that deletion of Lys107 results in a reorganization of the apoprotein structure that decreases its potential to form hydrophobic associations.
Authors:
G Ponsin; A M Gotto; G Utermann; H J Pownall
Related Documents :
8354954 - Cholesterol 7 alpha-hydroxylase: evidence for transcriptional regulation by cholesterol...
18467104 - Design and evaluation of a novel series of 2,3-oxidosqualene cyclase inhibitors with lo...
1637294 - Quantification of apolipoprotein b-48 and b-100 in rat liver endoplasmic reticulum and ...
6533274 - Effects of okinawan sugar cane wax and fatty alcohol on serum and liver lipids in the rat.
3324284 - 2,2,2-trifluoroethanol-induced enteropathy in rats: chemically or bacterially mediated ...
16419494 - The role of non-calcemic analogs of vitamin d in differentiation of cultured rat bone m...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  133     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-02-12     Completed Date:  1986-02-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  856-62     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Apolipoprotein A-I
Apolipoproteins A / metabolism*
Chromatography, Gel
Circular Dichroism
Female
Humans
Lipoproteins, HDL / metabolism*
Protein Binding
Rats
Rats, Inbred Strains
Spectrometry, Fluorescence
Grant Support
ID/Acronym/Agency:
HL27341/HL/NHLBI NIH HHS; HL30914/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoprotein A-I; 0/Apolipoproteins A; 0/Lipoproteins, HDL

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Biological activity of platelet activating factor-amidophosphonate (PAF-AP), a novel phosphonolipid ...
Next Document:  In vitro PGE2 synthesis by seminal vesicular microsomes: hysteretic behaviour in the presence of cal...