Document Detail

Abnormal integrity of association fiber tracts in amnestic mild cognitive impairment.
MedLine Citation:
PMID:  19162279     Owner:  NLM     Status:  MEDLINE    
The association fiber tracts integrity of the inter-hemispheric and within-hemispheric communication was poor understood in amnestic type mild cognitive impairment (aMCI) patients by diffusion tensor imaging (DTI). A region of interest-based DTI approach was applied to explore fiber tract differences between 22 aMCI patients and 22 well-matched normal aging. Correlations were also sought between fractional anisotropy (FA) values and the cognitive performance scores in the aMCI patients. Extensive impairment of association fiber tracts integrity was observed in aMCI patients, including bilateral inferior fronto-occipital fascicles, the genu of corpus callosum, bilateral cingulate bundles and bilateral superior longitudinal fascicles II (SLE II) subcomponent. In addition, the FA value of right SLE II was significantly negatively correlated to the performance of Trail Making Test A and B, whilst the values of right posterior cingulate bundle was significantly positive correlation with MMSE score. As aMCI is a putative prodromal syndrome to Alzheimer's disease (AD), this study suggested that investigation of association fiber tracts between remote cortexes may yield important new data to predict whether a patient will eventually develop AD.
Feng Bai; Zhijun Zhang; David R Watson; Hui Yu; Yongmei Shi; Yonggui Yuan; Yun Qian; Jianping Jia
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-21
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  278     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-02-02     Completed Date:  2009-05-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  102-6     Citation Subset:  IM    
School of Clinical Medicine, Southeast University, and the Department of Neurology, Affiliated ZhongDa Hospital of Southeast University, Nanjing 210009, China.
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MeSH Terms
Brain / pathology*
Brain Mapping
Cognition Disorders / pathology*
Magnetic Resonance Imaging
Neural Pathways / pathology
Neuropsychological Tests
Statistics, Nonparametric

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