| Abnormal hormone levels in men with coronary artery disease. | |
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MedLine Citation:
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PMID: 6460495 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plasma concentrations and urinary excretions of various hormones and hormone metabolites were measured in four groups. Group 1 was composed of 13 men with prior myocardial infarction; Group 2 contained 35 clinically normal men; Group 3 consisted of 44 men with normal coronary arteriograms; and Group 4 was composed of 25 men with severe coronary artery disease shown on arteriogram but no infarction. There were four major findings: Group 1 had significantly higher 24-hour mean plasma concentrations of estrone (E1), dehydroisoandrosterone (DHA), and dehydroisoandrosterone sulfate (DHAS) than Group 2, while Group 3 had the same levels as Group 4; Group 4 had significantly lower urinary excretion of androsterone glucuronide (AG) than Group 3, while Group 1 excreted normal amounts. There are three possible explanations for these findings: 1) myocardial infarction occurring in men with coronary artery disease may elevate the plasma levels of E1, DHA, and DHAS and eliminate the preinfarction depression of urinary AG levels; 2) higher than average levels of E1, DHA, DHAS, and AG may favor the development of infarction in men with coronary artery disease; 3) higher than average levels of E1, DHA, DHAS, and AG may favor survival from any infarction that occurs in men with coronary artery disease. Experimental and epidemiological evidence seems to favor the third possibility. |
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Authors:
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B Zumoff; R G Troxler; J O'Connor; R S Rosenfeld; J Kream; J Levin; J R Hickman; A M Sloan; W Walker; R L Cook; D K Fukushima |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Arteriosclerosis (Dallas, Tex.) Volume: 2 ISSN: 0276-5047 ISO Abbreviation: Arteriosclerosis Publication Date: 1982 Jan-Feb |
Date Detail:
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Created Date: 1982-04-22 Completed Date: 1982-04-22 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8401388 Medline TA: Arteriosclerosis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 58-67 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Androsterone / blood, urine Coronary Disease / blood*, urine Dehydroepiandrosterone / blood Estrone / blood Hormones / blood*, urine Humans Male Middle Aged Myocardial Infarction / blood*, urine Triiodothyronine / blood |
| Grant Support | |
ID/Acronym/Agency:
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RR-53/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hormones; 53-16-7/Estrone; 53-41-8/Androsterone; 53-43-0/Dehydroepiandrosterone; 6893-02-3/Triiodothyronine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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