| Abnormal heart rate variability as a manifestation of autonomic dysfunction in hemispheric brain infarction. | |
| | |
MedLine Citation:
|
PMID: 8898816 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND PURPOSE: Abnormal heart rate variability is related to prognostically unfavorable ventricular arrhythmias and sudden arrhythmic death in coronary artery disease. Short-term electrocardiographic (ECG) recordings have shown similar abnormalities of heart rate variability in patients with acute stroke. However, there is no information regarding the clinical significance of these abnormalities and of heart rate variability in long-term ECG recordings in stroke. METHODS: In this prospective study, we analyzed the time domain and frequency domain measures of heart rate variability from 24-hour ECG recordings in 31 consecutive patients with hemispheric brain infarction in the acute phase and at 1 and 6 months after the infarction and in 31 age- and sex-matched healthy control subjects. RESULTS: All the measured components of heart rate variability, ie, standard deviation of RR intervals (P < .001), total power (P < .0001), very-low-frequency power (P < .0001), low-frequency power (P < .001), and high-frequency power (P < .05), were significantly lower than those of the control subjects in both the acute phase and 1 and 6 months later. Impaired heart rate variability correlated with the severity of neurological deficits and disability. In five patients with increased intracranial pressure due to large brain infarction, no relevant spectral components were found. CONCLUSIONS: Hemispheric brain infarction seems to cause significant long-lasting damage to the cardiovascular autonomic regulatory system manifested as abnormalities of heart rate variability. Distorted heart rate variability in the acute phase of stroke may be prognostically unfavorable. |
| | |
Authors:
|
J T Korpelainen; K A Sotaniemi; H V Huikuri; V V Myllyä |
Related Documents
:
|
9167226 - Computerized system for assessing heart rate variability. 10097226 - Long-term beta-blocker therapy improves autonomic nervous regulation in advanced conges... 2337186 - Effects of deafferentation or sequential occlusions on cardiac sympathetic activity dur... 20196976 - N-3 fatty acids and cardiac autonomic function in humans. 2257716 - Ventricular tachycardia and ventricular aneurysm due to unrecognized sarcoidosis. 6778166 - Percutaneous transluminal angioplasty: general principles. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Stroke; a journal of cerebral circulation Volume: 27 ISSN: 0039-2499 ISO Abbreviation: Stroke Publication Date: 1996 Nov |
Date Detail:
|
Created Date: 1996-12-05 Completed Date: 1996-12-05 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0235266 Medline TA: Stroke Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 2059-63 Citation Subset: IM |
Affiliation:
|
Department of Neurology, University of Oulu, Finland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Adult Aged Autonomic Nervous System / physiopathology* Case-Control Studies Cerebral Infarction / physiopathology* Electrocardiography, Ambulatory / methods Female Follow-Up Studies Heart Rate* Humans Male Middle Aged Prospective Studies Severity of Illness Index Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dissociation of vasoreactivity to acetazolamide and hypercapnia. Comparative study in patients with ...
Next Document: Serum neuron-specific enolase, carnosinase, and their ratio in acute stroke. An enzymatic test for p...