Document Detail


Abnormal growth of cultured skin fibroblasts associated with poor premorbid history in schizophrenic patients.
MedLine Citation:
PMID:  7841136     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The relations of abnormal growth of cultured skin fibroblasts, as manifest in prolonged doubling time, and a history of impaired childhood premorbid functioning, separately for social and school (instrumental) functioning were examined in 22 schizophrenic patients. Prolonged doubling time (> 2 weeks) was significantly associated with poorer childhood social functioning, even after controlling for variance due to age, sex, race, and age at onset of illness. Doubling time was not associated with school performance scores. The findings indicate that the cellular or molecular process(es) underlying abnormal growth of skin fibroblasts may be involved in, or associated with, aberrant biological processes that contribute to early dyssocial behavior in schizophrenic patients.
Authors:
S Mukherjee; S P Mahadik; D B Schnur; H Laev; R Reddy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Schizophrenia research     Volume:  13     ISSN:  0920-9964     ISO Abbreviation:  Schizophr. Res.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-03-08     Completed Date:  1995-03-08     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  233-7     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Medical College of Georgia, Augusta 30912-3800.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cell Division / physiology*
Cells, Cultured
Educational Status
Female
Fibroblasts / physiology
Humans
Male
Personality Development
Psychiatric Status Rating Scales
Schizophrenia / diagnosis,  physiopathology*
Schizophrenic Psychology*
Schizotypal Personality Disorder / diagnosis,  physiopathology*,  psychology
Social Adjustment*
Grant Support
ID/Acronym/Agency:
MH41961/MH/NIMH NIH HHS; MH46546/MH/NIMH NIH HHS; MH47002/MH/NIMH NIH HHS
Comments/Corrections
Comment In:
Schizophr Res. 1995 Aug 1;16(2):171-2   [PMID:  7577771 ]

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