Document Detail

Abnormal function of the brain system supporting motivated attention in medicated patients with schizophrenia: an fMRI study.
MedLine Citation:
PMID:  16650349     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Patients with schizophrenia have an impaired ability to generate activity that is appropriate to current circumstances and goals.
METHOD: We report a study using functional magnetic resonance imaging (fMRI) to examine cerebral activity during a three-tone auditory oddball target detection task in a sample of 28 patients with schizophrenia and 28 healthy controls.
RESULTS: The patients exhibited significantly less activation in response to target stimuli relative to baseline in an extensive set of sites in association neocortex, paralimbic cortex, limbic structures and subcortical nuclei, yet demonstrated a normal level of activation in the sensorimotor cortex. Comparison of activity elicited by rare target stimuli with that elicited by equally rare novel stimuli makes it possible to distinguish cerebral activity associated with attention to behaviourally salient stimuli from activity associated with attending to other attention-capturing stimuli. This comparison revealed that the patients with schizophrenia also exhibited a deficit in activation of basal forebrain areas that mediate motivation during the processing of behaviourally salient stimuli, including the amygdala, ventral striatum, orbital frontal cortex and rostral anterior cingulate cortex.
CONCLUSION: Patients with schizophrenia have a deficit in function of the brain system concerned with mediating motivation, in addition to a more general deficit in the cerebral response to attention-captivating stimuli.
Peter F Liddle; Kristin R Laurens; Kent A Kiehl; Elton T C Ngan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-05-02
Journal Detail:
Title:  Psychological medicine     Volume:  36     ISSN:  0033-2917     ISO Abbreviation:  Psychol Med     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-20     Completed Date:  2006-12-22     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  1254142     Medline TA:  Psychol Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  1097-108     Citation Subset:  IM    
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MeSH Terms
Acoustic Stimulation
Antipsychotic Agents / therapeutic use
Arousal / drug effects,  physiology*
Attention / drug effects,  physiology*
Brain / drug effects,  physiopathology*
Brain Mapping
Image Processing, Computer-Assisted*
Limbic System / drug effects,  physiopathology
Magnetic Resonance Imaging*
Neocortex / drug effects,  physiopathology
Nerve Net / drug effects,  physiopathology
Pitch Discrimination / drug effects,  physiology*
Reference Values
Thalamus / drug effects,  physiopathology
Grant Support
G9900259//Medical Research Council
Reg. No./Substance:
0/Antipsychotic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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