| Abnormal fatty acid profile in chronic hemodialysis patients: possible deficiency of essential fatty acids. | |
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MedLine Citation:
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PMID: 2129482 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plasma fatty acid profiles from maintenance hemodialysis patients (n = 9) were compared with those from healthy volunteers (n = 9). Hemodialysis patients had significantly higher levels of oleic acid, 15.3 +/- 1.1 vs. 8.9 +/- 0.6% (p less than 0.0001), and lower levels of arachidonic acid (6.0 +/- 0.5 vs. 8.4 +/- 0.3%, p less than 0.0009). Linolenic and linoleic acids, the essential fatty acid and precursors of arachidonic acid, were also significantly lower than normal in the dialysis group. These data show that dialysis patients have fatty acid abnormalities suggesting relative depletion of essential fatty acids. These observations are important because these abnormalities may play an important role in the pathogenesis of some common clinical conditions associated with uremia, such as a constellation of skin problems, fragility of erythrocytes, lipid anomalies and hormonal aberrations. |
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Authors:
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A Dasgupta; M A Kenny; S Ahmad |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical physiology and biochemistry Volume: 8 ISSN: 0252-1164 ISO Abbreviation: Clin Physiol Biochem Publication Date: 1990 |
Date Detail:
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Created Date: 1991-10-16 Completed Date: 1991-10-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8305885 Medline TA: Clin Physiol Biochem Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 238-43 Citation Subset: IM |
Affiliation:
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Department of Pathology, University of Chicago Prizker School of Medicine, Ill. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Arachidonic Acid Arachidonic Acids / blood Fatty Acids / blood* Fatty Acids, Essential / blood, deficiency* Female Humans Linoleic Acid Linoleic Acids / blood Linolenic Acids / blood Male Middle Aged Oleic Acid Oleic Acids / blood Renal Dialysis* |
| Chemical | |
Reg. No./Substance:
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0/Arachidonic Acids; 0/Fatty Acids; 0/Fatty Acids, Essential; 0/Linoleic Acids; 0/Linolenic Acids; 0/Oleic Acids; 112-80-1/Oleic Acid; 2197-37-7/Linoleic Acid; 506-12-7/margaric acid; 506-32-1/Arachidonic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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