Document Detail

Abnormal fatty acid profile in chronic hemodialysis patients: possible deficiency of essential fatty acids.
MedLine Citation:
PMID:  2129482     Owner:  NLM     Status:  MEDLINE    
Plasma fatty acid profiles from maintenance hemodialysis patients (n = 9) were compared with those from healthy volunteers (n = 9). Hemodialysis patients had significantly higher levels of oleic acid, 15.3 +/- 1.1 vs. 8.9 +/- 0.6% (p less than 0.0001), and lower levels of arachidonic acid (6.0 +/- 0.5 vs. 8.4 +/- 0.3%, p less than 0.0009). Linolenic and linoleic acids, the essential fatty acid and precursors of arachidonic acid, were also significantly lower than normal in the dialysis group. These data show that dialysis patients have fatty acid abnormalities suggesting relative depletion of essential fatty acids. These observations are important because these abnormalities may play an important role in the pathogenesis of some common clinical conditions associated with uremia, such as a constellation of skin problems, fragility of erythrocytes, lipid anomalies and hormonal aberrations.
A Dasgupta; M A Kenny; S Ahmad
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical physiology and biochemistry     Volume:  8     ISSN:  0252-1164     ISO Abbreviation:  Clin Physiol Biochem     Publication Date:  1990  
Date Detail:
Created Date:  1991-10-16     Completed Date:  1991-10-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8305885     Medline TA:  Clin Physiol Biochem     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  238-43     Citation Subset:  IM    
Department of Pathology, University of Chicago Prizker School of Medicine, Ill.
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MeSH Terms
Aged, 80 and over
Arachidonic Acid
Arachidonic Acids / blood
Fatty Acids / blood*
Fatty Acids, Essential / blood,  deficiency*
Linoleic Acid
Linoleic Acids / blood
Linolenic Acids / blood
Middle Aged
Oleic Acid
Oleic Acids / blood
Renal Dialysis*
Reg. No./Substance:
0/Arachidonic Acids; 0/Fatty Acids; 0/Fatty Acids, Essential; 0/Linoleic Acids; 0/Linolenic Acids; 0/Oleic Acids; 112-80-1/Oleic Acid; 2197-37-7/Linoleic Acid; 506-12-7/margaric acid; 506-32-1/Arachidonic Acid

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