| Abnormal fatty acid composition of lymphocytes of biotin-deficient rats. | |
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MedLine Citation:
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PMID: 7965217 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The relative proportions (% of total fatty acids) of odd-chain (15:0-29:0) and long-chain (22:0-30:0) saturated fatty acids in phospholipids of biotin-deficient rat lymphocytes were significantly increased as compared with biotin-supplemented rats, and the ratio of unsaturated fatty acids to saturated fatty acids in the former was significantly decreased mainly due to the reduced composition of polyunsaturated fatty acids in the omega-3, omega-6, and omega-9 pathway. The ratio of cis-vaccenic acid to palmitoleic acid in biotin-deficient rats was significantly lower than that in control rats, and was thought to be another important, but previously unreported indicator of biotin deficiency. These changes imply that the elongation and desaturation of unsaturated fatty acids are depressed in lymphocytes of biotin-deficient rats, and may contribute to the associated immunological dysfunction in biotin deficiency through abnormal prostaglandin metabolism and/or cell membrane functions. |
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Authors:
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Y Y Liu; Y Shigematsu; I Bykov; A Nakai; Y Kikawa; T Fukui; M Sudo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of nutritional science and vitaminology Volume: 40 ISSN: 0301-4800 ISO Abbreviation: J. Nutr. Sci. Vitaminol. Publication Date: 1994 Jun |
Date Detail:
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Created Date: 1994-12-16 Completed Date: 1994-12-16 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0402640 Medline TA: J Nutr Sci Vitaminol (Tokyo) Country: JAPAN |
Other Details:
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Languages: eng Pagination: 283-8 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Fukui Medical School, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biotin / deficiency* Fatty Acids / blood* Fatty Acids, Monounsaturated / blood Fatty Acids, Unsaturated / blood Lymphocytes / metabolism* Male Oleic Acids / blood Phospholipids / blood Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Fatty Acids, Monounsaturated; 0/Fatty Acids, Unsaturated; 0/Oleic Acids; 0/Phospholipids; 2091-29-4/palmitoleic acid; 506-17-2/cis-vaccenic acid; 58-85-5/Biotin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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