| Abnormal eye-head coordination in Parkinson's disease patients after administration of levodopa: a possible substrate of levodopa-induced dyskinesia. | |
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MedLine Citation:
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PMID: 3489074 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Head oscillations in response to whole body oscillation of Parkinsonian patients before and after administration of levodopa were compared with those of normal subjects. Parkinsonian patients developed large increases in the amplitude of their head movements while fixating a stationary target after administration of levodopa. This increase was proportional to disease severity and was maximal in stage IV patients with levodopa induced dyskinesias. These findings indicate a fundamental yet reversible change in the strategy of eye-head coordination in Parkinsonian patients after administration of levodopa which may be due to release of normally inhibited visuo-vestibular reflexes. |
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Authors:
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M Weinrich; R Bhatia |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of neurology, neurosurgery, and psychiatry Volume: 49 ISSN: 0022-3050 ISO Abbreviation: J. Neurol. Neurosurg. Psychiatr. Publication Date: 1986 Jul |
Date Detail:
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Created Date: 1986-10-03 Completed Date: 1986-10-03 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985191R Medline TA: J Neurol Neurosurg Psychiatry Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 785-90 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Dyskinesia, Drug-Induced / etiology*, physiopathology Eye Movements Head Humans Levodopa / adverse effects* Middle Aged Movement* Parkinson Disease / drug therapy*, physiopathology Reflex, Abnormal / physiopathology* Vestibule, Labyrinth / physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Levodopa |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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