Document Detail

Abnormal expression of tyrosine hydroxylase immunoreactivity in cerebellar cortex of ataxic mutant mice.
MedLine Citation:
PMID:  10350535     Owner:  NLM     Status:  MEDLINE    
Expression of tyrosine hydroxylase (TH) was examined immunohistochemically in the cerebellum of two ataxic mutants, Rolling mouse Nagoya (RMN) and dilute-lethal mice (DL). In littermate controls of both mutants, a few TH-positive Purkinje cells were distributed sparsely and their number was smaller than in the mutants at any ages examined. In RMN, TH-positive Purkinje cells were distributed in lobule IX and X, and were arranged into parasagittal bands at 2 weeks of age. TH-positive Purkinje cells increased in number and were widely distributed throughout the vermis at 3 weeks of age. In adult RMN, TH-positive Purkinje cells were found in all lobules of the cerebellum. Their parasagittal bands also became evident in the hemisphere. In DL, TH-positive Purkinje cells were mainly distributed in vermal lobules IX and X, and the flocculus at 3 weeks of age. They were also found as bands in lobules IX and X. The results suggest that abnormal expression of TH in Purkinje cells may not be specific to the allelic group. Since TH promoter is activated by Ca2+, TH expression in the mutant Purkinje cells may predict neuronal dysfunction caused by alterations in cellular Ca2+ currents.
K Sawada; S Komatsu; H Haga; X Z Sun; S Hisano; Y Fukui
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  829     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-08-02     Completed Date:  1999-08-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  107-12     Citation Subset:  IM    
Copyright Information:
Copyright 1999 Elsevier Science B.V.
Department of Anatomy, School of Medicine, Tokushima University, Tokushima 770-8503, Japan.
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MeSH Terms
Calcium Channels / physiology
Cerebellar Ataxia / enzymology*
Mice, Neurologic Mutants
Neurons / enzymology*
Tyrosine 3-Monooxygenase / analysis*
Reg. No./Substance:
0/Calcium Channels; EC 3-Monooxygenase

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