| Abnormal development of blood pressure and growth in rats exposed to perinatal injection stress. | |
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MedLine Citation:
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PMID: 6855452 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Subcutaneous injections of alkaline saline were made perinatally in Sprague-Dawley rats according to two schedules. In a pre-/postnatal group, dams were treated from 19th gestational day to 9th day postpartum and pups from day 0-9. In a postnatal group, pups alone were injected from day 0-6. At 19-23, 50-56 and 82-86 days of age, injected rats and uninjected controls were anesthetized and arterial blood pressure measured. Rats from the pre-/postnatal group had higher blood pressures (58%) and body weights at 19-23 days and lower blood pressure (35%) and body weight at 82-86 days of age. Blood pressure and body weight were comparable to control at all ages in the postnatal injection group. It is concluded that as a result of the maternal stress produced by the injections there was a generalized disturbance of growth processes resulting in hypotension and decreased body weight in adulthood. |
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Authors:
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P G Smith; E Mills |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Life sciences Volume: 32 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1983 May |
Date Detail:
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Created Date: 1983-07-08 Completed Date: 1983-07-08 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 2497-501 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging* Animals Blood Pressure* Body Weight Female Fetus / physiology* Growth* Injections, Subcutaneous Pregnancy Pregnancy Complications / physiopathology* Rats Rats, Inbred Strains Sodium Chloride / administration & dosage Stress, Physiological / embryology, physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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HL 29403-01/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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