| Abnormal delayed-type hypersensitivity in mice born to females treated with vitamin A during pregnancy. | |
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MedLine Citation:
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PMID: 1490009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of vitamin A (retinolum palmiticum) administered to pregnant mice on the cell-mediated immunity of the offspring were studied in random-bred ICR mice. Delayed-type hypersensitivity (DTH) to sheep red blood cells was assayed after immunization of the control and experimental young in the 4th postnatal week. The administration of vitamin A, in doses of 5,000 IU, on days 15-17 of pregnancy depressed DTH of the female offspring. On the other hand, the administration of single doses of 5,000 and 10,000 IU on the 16th day of pregnancy increased DTH in the offspring. The effects were correlated to the sex and body weight of the offspring, the highest DTH being observed in the female offspring with a low body weight. |
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Authors:
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M Dostál; D Soukupová |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Functional and developmental morphology Volume: 2 ISSN: 0862-8416 ISO Abbreviation: Funct Dev Morphol Publication Date: 1992 |
Date Detail:
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Created Date: 1993-03-02 Completed Date: 1993-03-02 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9200392 Medline TA: Funct Dev Morphol Country: CZECHOSLOVAKIA |
Other Details:
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Languages: eng Pagination: 157-62 Citation Subset: IM |
Affiliation:
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Institute of Experimental Medicine, Czechoslovak Academy of Sciences, Prague. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Drug Hypersensitivity / etiology* Female Hypersensitivity, Delayed / chemically induced* Mice Mice, Inbred ICR Pregnancy Prenatal Exposure Delayed Effects* Vitamin A / toxicity* |
| Chemical | |
Reg. No./Substance:
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11103-57-4/Vitamin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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